Expression of GP88 (progranulin) in serum of prostate cancer patients is associated with Gleason scores and overall survival

Greither T, Fischer K, Theil G, Marcou M, Holzhausen HJ, Weigelt K, Serrero G, Hicks D, Yue B, Fornara P, Wullich B, Taubert H, Wach S, Lieb V (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Cancer Management and Research Dove Medical Press

Book Volume: 10

Pages Range: 4173-4180

DOI: 10.2147/CMAR.S172069

Abstract

Background: GP88/Progranulin is a well-recognized cell growth promoter in different cancers, and elevated serum GP88 levels have been described as negative prognostic factor in breast cancer. However, serum levels in prostate cancer (PCa) patients have not yet been studied. Material and Methods: We analyzed serum GP88 levels by enzyme immunosorbent assay and correlated them with clinicopathological parameters in PCa patients. PCa patients were separated into two groups based on the serum GP88 median level (low <= 44.56 ng/mL or high >44.56 ng/mL) and according to their median age (younger <= 66 years or elder patients >66 years). Results: Low serum GP88 levels were more often detected in younger patients and high levels in elder patients (P=0.018; Fisher's exact test). PCa patients were separated into three groups, Gleason score (GS) <= 6; GS=7; and GS >= 8. In receiver operating characteristic analyses, we could distinguish GS <= 6 from GS=7 [area under the curve (AUC): 0.646; P=0.018] and GS <= 6 from GS >= 8 (AUC: 0.629; P=0.048) but not GS=7 from GS >= 8. For survival analysis, GP88 levels were separated into two groups by an optimized cutoff value of 36.92 ng/mL. Using this GP88 stratification, all PCa patients and younger patients with a low serum GP88 level had a significantly better overall survival compared with patients with higher serum GP88 levels (log-rank test P=0.010 and P=0.024). Conclusion: Serum GP88 levels are significantly different depending on age and GS, and they are associated with the prognosis of PCa patients.

Authors with CRIS profile

Bernd Wullich Lehrstuhl für Urologie Helge Taubert Urologische Klinik

Involved external institutions

Martin-Luther-Universität Halle-Wittenberg (MLU) DE Germany (DE) A&G Pharmaceutical US United States (USA) (US)

How to cite

APA:

Greither, T., Fischer, K., Theil, G., Marcou, M., Holzhausen, H.-J., Weigelt, K.,... Lieb, V. (2018). Expression of GP88 (progranulin) in serum of prostate cancer patients is associated with Gleason scores and overall survival. Cancer Management and Research , 10, 4173-4180. https://doi.org/10.2147/CMAR.S172069

MLA:

Greither, Thomas, et al. "Expression of GP88 (progranulin) in serum of prostate cancer patients is associated with Gleason scores and overall survival." Cancer Management and Research 10 (2018): 4173-4180.

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