Factors associated with p-phenylenediamine sensitization: data from the Information Network of Departments of Dermatology, 2008-2013
Schubert S, Lessmann H, Schnuch A, Uter W, Geier J (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 78
Pages Range: 199-207
Journal Issue: 3
DOI: 10.1111/cod.12920
Abstract
BACKGROUND: Risk factors for p-phenylenediamine (PPD) sensitization include the use of hair dyes, the application of temporary black henna tattoos, working as a hairdresser, and, possibly, exposure to hair dye pretests. OBJECTIVES: To quantify the impact of these (putative) risk factors on PPD sensitization. METHODS: Six items related to PPD exposure were added to the routine Information Network of Departments of Dermatology questionnaire from 2008 to 2013. A retrospective analysis of data from 4314 patients tested with PPD 1% pet. was conducted. RESULTS: Of the PPD-positive patients (n = 271), 80% had their hair dyed, and, of these, 57% subsequently developed scalp dermatitis, whereas only 11% had had a henna tattoo. The self-administrated pretest with hair dye was performed by only a few patients, precluding a more detailed analysis. Hair dyeing [odds ratio (OR) 6.0; 95% confidence interval (CI): 3.9-9.4], henna tattoos (OR 2.4; 95%CI: 1.5-3.7) and being a hairdresser (OR 2.1; 95%CI: 1.3-3.2) increased the risk of PPD sensitization. Neither dyeing of own hair nor application of a temporary henna tattoo seemed to affect PPD sensitization in hairdressers. p-Aminoaryl compounds more often gave positive reactions in patients with henna tattoo. CONCLUSIONS: Hair dyeing is the major risk factor for PPD sensitization in this clinical setting, and application of a temporary black henna tattoo may also lead to (strong) PPD sensitization.
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APA:
Schubert, S., Lessmann, H., Schnuch, A., Uter, W., & Geier, J. (2018). Factors associated with p-phenylenediamine sensitization: data from the Information Network of Departments of Dermatology, 2008-2013. Contact Dermatitis, 78(3), 199-207. https://doi.org/10.1111/cod.12920
MLA:
Schubert, Steffen, et al. "Factors associated with p-phenylenediamine sensitization: data from the Information Network of Departments of Dermatology, 2008-2013." Contact Dermatitis 78.3 (2018): 199-207.
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