Effects of Levetiracetam and Sulthiame on EEG in benign epilepsy with centrotemporal spikes: A randomized controlled trial
Tacke M, Borggraefe I, Gerstl L, Heinen F, Vill K, Bonfert M, Bast T, Neubauer BA, Baumeister F, Baethmann M, Bentele K, Blank C, Blank HM, Bode H, Bosch F, Brandl U, Brockmann K, Dahlem P, Ernst JP, Feldmann E, Fiedler A, Gerigk M, Hess S, Hikel C, Hoffmann HG, Kieslich M, Klepper J, Kluger G, Koch H, Koch W, Korinthenberg R, Krois I, Kuehne H, Kurlemann G, Mandl M, Mause U, Navratil P, Opp J, Penzien J, Prietsch V, Quattlaender A, Rating D, Schara U, Shamdeen MG, Sprinz A, Wendker-Magrabi H, Stephani U, Muhle H, Strassburg HM, Toepke B, Trollmann R, Tuschen-Hofstaetter E, Waltz S, Weber G, Wien FU, Wolff' M, Polster T, Freitag H, Soenmez O, Reinhardt K, Traus M, Hoovey Z (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 56
Pages Range: 115-120
DOI: 10.1016/j.seizure.2018.01.015
Abstract
PURPOSE: BECTS (benign childhood epilepsy with centrotemporal spikes) is associated with characteristic EEG findings. This study examines the influence of anti-convulsive treatment on the EEG. METHODS: In a randomized controlled trial including 43 children with BECTS, EEGs were performed prior to treatment with either Sulthiame or Levetiracetam as well as three times under treatment. Using the spike-wave-index, the degree of EEG pathology was quantified. The EEG before and after initiation of treatment was analyzed. Both treatment arms were compared and the EEG of the children that were to develop recurrent seizures was compared with those that were successfully treated. RESULTS: Regardless of the treatment agent, the spike-wave-index was reduced significantly under treatment. There were no differences between the two treatment groups. In an additional analysis, the EEG characteristics of the children with recurrent seizures differed statistically significant from those that did not have any further seizures. CONCLUSION: Both Sulthiame and Levetiracetam influence the EEG of children with BECTS. Persistent EEG pathologies are associated with treatment failures.
Authors with CRIS profile
Involved external institutions
Klinikum Frankfurt Höchst
Germany (DE)
Paracelsus Medizinische Privatuniversität
Austria (AT)
Justus-Liebig-Universität Gießen
Germany (DE)
Universitätsklinikum Münster
Germany (DE)
Universitätsklinikum Jena
Germany (DE)
HELIOS Kliniken
Germany (DE)
Universität Koblenz-Landau
Germany (DE)
Klinikum Landshut
Germany (DE)
Clemenshospital
Germany (DE)
Klinikum Dritter Orden
Germany (DE)
Bethel Epilepsy Center
Germany (DE)
Epilepsiezentrum Kork
Germany (DE)
Universität Duisburg-Essen (UDE)
Germany (DE)
Germany (DE)
Paracelsus Medizinische Privatuniversität
Austria (AT)
Justus-Liebig-Universität Gießen
Germany (DE)
Universitätsklinikum Münster
Germany (DE)
Universitätsklinikum Jena
Germany (DE)
HELIOS Kliniken
Germany (DE)
Universität Koblenz-Landau
Germany (DE)
Klinikum Landshut
Germany (DE)
Clemenshospital
Germany (DE)
Klinikum Dritter Orden
Germany (DE)
Bethel Epilepsy Center
Germany (DE)
Epilepsiezentrum Kork
Germany (DE)
Universität Duisburg-Essen (UDE)
Germany (DE)
How to cite
APA:
Tacke, M., Borggraefe, I., Gerstl, L., Heinen, F., Vill, K., Bonfert, M.,... Hoovey, Z. (2018). Effects of Levetiracetam and Sulthiame on EEG in benign epilepsy with centrotemporal spikes: A randomized controlled trial. Seizure-European Journal of Epilepsy, 56, 115-120. https://dx.doi.org/10.1016/j.seizure.2018.01.015
MLA:
Tacke, Moritz, et al. "Effects of Levetiracetam and Sulthiame on EEG in benign epilepsy with centrotemporal spikes: A randomized controlled trial." Seizure-European Journal of Epilepsy 56 (2018): 115-120.
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