Design and methodology of the screening for CKD among older patients across Europe (SCOPE) study: a multicenter cohort observational study

Corsonello A, Tap L, Roller-Wirnsberger R, Wirnsberger G, Zoccali C, Kostka T, Guligowska A, Mattace-Raso F, Gil P, Guardado Fuentes L, Meltzer I, Yehoshua I, Formiga-Perez F, Moreno-Gonzalez R, Weingart C, Freiberger E, Arnlov J, Carlsson AC, Bustacchini S, Lattanzio F (2018)

Publication Type: Journal article

Publication year: 2018

Journal

BMC Nephrology BMC

Book Volume: 19

DOI: 10.1186/s12882-018-1030-2

Abstract

Background: Decline of renal function is common in older persons and the prevalence of chronic kidney disease (CKD) is rising with ageing. CKD affects different outcomes relevant to older persons, additionally to morbidity and mortality which makes CKD a relevant health burden in this population. Still, accurate laboratory measurement of kidney function is under debate, since current creatinine-based equations have a certain degree of inaccuracy when used in the older population. The aims of the study are as follows: to assess kidney function in a cohort of 75+ older persons using existing methodologies for CKD screening; to investigate existing and innovative biomarkers of CKD in this cohort, and to align laboratory and biomarker results with medical and functional data obtained from this cohort. The study was registered at ClinicalTrials.gov, identifier NCT02691546, February 25th 2016. Methods/design: An observational, multinational, multicenter, prospective cohort study in community dwelling persons aged 75 years and over, visiting the outpatient clinics of participating institutions. The study will enroll 2450 participants and is carried out in Austria, Germany, Israel, Italy, the Netherlands, Poland and Spain. Participants will undergo clinical and laboratory evaluations at baseline and after 12 and 24 months-follow-up. Clinical evaluation also includes a comprehensive geriatric assessment (CGA). Local laboratory will be used for 'basic' parameters (including serum creatinine and albumin-to-creatinine ratio), whereas biomarker assessment will be conducted centrally. An intermediate telephone follow-up will be carried out at 6 and 18 months. Discussion: Combining the use of CGA and the investigation of novel and existing independent biomarkers within the SCOPE study will help to provide evidence in the development of European guidelines and recommendations in the screening and management of CKD in older people.

Authors with CRIS profile

Ellen Freiberger Lehrstuhl für Innere Medizin (Geriatrie)

Involved external institutions

Medical University of Łódź / Uniwersytet Medyczny w Łodzi PL Poland (PL) Erasmus University Rotterdam (EUR) / Erasmus Universiteit Rotterdam NL Netherlands (NL) Bellvitge University Hospital / Hospital Universitari de Bellvitge ES Spain (ES) Istituto Nazionale di Riposo e Cura per Anziani (IRCCS INRCA) IT Italy (IT) Hospital Clínico San Carlos ES Spain (ES) Maccabi Healthcare IL Israel (IL) Azienda Ospedaliera "Bianchi Melacrino Morelli", Reggio Calabria IT Italy (IT) Uppsala University SE Sweden (SE) Ben-Gurion University of the Negev (BGU) / אוניברסיטת בן-גוריון בנגב IL Israel (IL)

How to cite

APA:

Corsonello, A., Tap, L., Roller-Wirnsberger, R., Wirnsberger, G., Zoccali, C., Kostka, T.,... Lattanzio, F. (2018). Design and methodology of the screening for CKD among older patients across Europe (SCOPE) study: a multicenter cohort observational study. BMC Nephrology, 19. https://dx.doi.org/10.1186/s12882-018-1030-2

MLA:

Corsonello, Andrea, et al. "Design and methodology of the screening for CKD among older patients across Europe (SCOPE) study: a multicenter cohort observational study." BMC Nephrology 19 (2018).

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