A Comparison of GFR Estimation Formulae in Pediatric Oncology

Rechenauer T, Zierk J, Graefe D, Rascher W, Rauh M, Metzler M (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Klinische Pädiatrie Georg Thieme Verlag

Book Volume: 230

Pages Range: 142-150

Journal Issue: 3

DOI: 10.1055/a-0587-5753

Abstract

BACKGROUND: Application of potentially nephrotoxic chemotherapy requires continuous monitoring of renal function for toxicity and dosing. Novel pediatric glomerular filtration rate (GFR) estimating equations including cystatin C have been proposed to enhance the reliability of GFR calculation. MATERIALS AND METHODS: We examined a pediatric oncologic data set with a total of 363 GFR measurements. An analysis of distribution characteristics and comparison of medians was performed to compare creatinine and cystatin C-based GFR estimating formulae. Furthermore, we investigated the clinical impact of different equations in regard to therapeutic consequences. RESULTS: Significant differences in estimated GFR values were calculated depending on the applied formula (range of median GFR from 94.8 to 180.9 mL/min per 1.73 m2) which may result in different therapeutic consequences for the use of potentially nephrotoxic chemotherapeutic agents. Significant correlation for all examined formulae was identified, however there were large fluctuations among the correlation coefficients ranging from 0.254 to 1.0. CONCLUSION: This study compares proposed pediatric GFR estimating equations in a clinical setting. It underlines the current limitations and difficulties of GFR estimation including potential dosing errors. Cystitis C-based equations can be used as alternatives to creatinine-based estimations when the appropriate laboratory method has been applied. A comparative calculator for pediatric GFR estimating equations along with background information is provided at http://gfr.pedz.de and may support clinical decision-making.

Authors with CRIS profile

Tobias Rechenauer Department of Paediatrics and Adolescent Medicine Jakob Zierk Department of Paediatrics and Adolescent Medicine Wolfgang Rascher Department of Paediatrics and Adolescent Medicine Manfred Rauh Department of Paediatrics and Adolescent Medicine Markus Metzler Professur für Kinder- und Jugendmedizin mit dem Schwerpunkt Pädiatrische Onkologie und Hämatologie

Involved external institutions

Universitätsklinikum Leipzig DE Germany (DE)

How to cite

APA:

Rechenauer, T., Zierk, J., Graefe, D., Rascher, W., Rauh, M., & Metzler, M. (2018). A Comparison of GFR Estimation Formulae in Pediatric Oncology. Klinische Pädiatrie, 230(3), 142-150. https://dx.doi.org/10.1055/a-0587-5753

MLA:

Rechenauer, Tobias, et al. "A Comparison of GFR Estimation Formulae in Pediatric Oncology." Klinische Pädiatrie 230.3 (2018): 142-150.

BibTeX: Download