A degradation fragment of type X collagen is a real-time marker for bone growth velocity

Coghlan RF, Oberdorf JA, Sienko S, Aiona MD, Boston BA, Connelly KJ, Bahney C, Larouche J, Almubarak SM, Coleman DT, Girkontaite I, von der Mark K, Lunstrum GP, Horton WA (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Science Translational Medicine American Association for the Advancement of Science

Book Volume: 9

Journal Issue: 419

DOI: 10.1126/scitranslmed.aan4669

Abstract

Despite its importance as a key parameter of child health and development, growth velocity is difficult to determine in real time because skeletal growth is slow and clinical tools to accurately detect very small increments of growth do not exist. We report discovery of a marker for skeletal growth in infants and children. The intact trimeric noncollagenous 1 (NC1) domain of type X collagen, the marker we designated as CXM for Collagen X Marker, is a degradation by-product of endochondral ossification that is released into the circulation in proportion to overall growth plate activity. This marker corresponds to the rate of linear bone growth at time of measurement. Serum concentrations of CXM plotted against age show a pattern similar to well-established height growth velocity curves and correlate with height growth velocity calculated from incremental height measurements in this study. The CXM marker is stable once collected and can be accurately assayed in serum, plasma, and dried blood spots. CXM testing may be useful for monitoring growth in the pediatric population, especially responses of infants and children with genetic and acquired growth disorders to interventions that target the underlying growth disturbances. The utility of CXM may potentially extend to managing other conditions such as fracture healing, scoliosis, arthritis, or cancer.

Authors with CRIS profile

Klaus von der Mark Medizinische Fakultät

Involved external institutions

Fordham University US United States (USA) (US) University of California San Francisco (UCSF) US United States (USA) (US) Shriners Hospitals for Children US United States (USA) (US) Oregon Health and Science University (OSHU) US United States (USA) (US)

How to cite

APA:

Coghlan, R.F., Oberdorf, J.A., Sienko, S., Aiona, M.D., Boston, B.A., Connelly, K.J.,... Horton, W.A. (2017). A degradation fragment of type X collagen is a real-time marker for bone growth velocity. Science Translational Medicine, 9(419). https://dx.doi.org/10.1126/scitranslmed.aan4669

MLA:

Coghlan, Ryan F., et al. "A degradation fragment of type X collagen is a real-time marker for bone growth velocity." Science Translational Medicine 9.419 (2017).

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