Dynamic reference intervals for coagulation parameters from infancy to adolescence

Weidhofer C, Meyer E, Ristl R, Wiedemann H, Cadamuro J, Kipman U, Zierk J, Male C, Quehenberger P, Haschke-Becher E, Einwallner E (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Clinica Chimica Acta Elsevier

Book Volume: 482

Pages Range: 124-135

DOI: 10.1016/j.cca.2018.04.003

Abstract

INTRODUCTION: Practical and ethical challenges as well as time and costs have restricted the generation of pediatric reference intervals. Therefore, pediatric reference intervals on coagulation parameters based on solid evidence are still scarce. Furthermore, reference intervals by age-group cannot reflect the dynamics of age and sex specific coagulation values during childhood. This study is the first to close this gap and provide continuous age and sex dependent reference intervals during childhood in hemostasis. METHODS: We used an innovative indirect method for providing continuous reference intervals for five common coagulation parameters: Activated partial thromboplastin time (aPTT), prothrombin time (PT), thrombin clotting time (TT), fibrinogen (FIB) and antithrombin (AT). Calculations were performed using retrospective laboratory data from pediatric patients between 2005 and 2015 of two major Austrian hospitals, resulting in a total of 195.360 measurements (aPTT: 55,100; PT: 35,492; TT: 35,295; FIB: 49,789; AT: 19,684). RESULTS: This multicenter study provides calculations of continuous reference intervals for five common coagulation parameters in a large pediatric cohort, accounting for age and gender. CONCLUSION: To the best of our knowledge, this is the first multicenter study, determining continuous pediatric coagulation reference intervals based on a large retrospective dataset.

Authors with CRIS profile

Jakob Zierk Department of Paediatrics and Adolescent Medicine

Involved external institutions

Medizinische Universität Wien AT Austria (AT) Paracelsus Medizinische Privatuniversität AT Austria (AT)

How to cite

APA:

Weidhofer, C., Meyer, E., Ristl, R., Wiedemann, H., Cadamuro, J., Kipman, U.,... Einwallner, E. (2018). Dynamic reference intervals for coagulation parameters from infancy to adolescence. Clinica Chimica Acta, 482, 124-135. https://dx.doi.org/10.1016/j.cca.2018.04.003

MLA:

Weidhofer, Christina, et al. "Dynamic reference intervals for coagulation parameters from infancy to adolescence." Clinica Chimica Acta 482 (2018): 124-135.

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