Differential conduction and CGRP release in visceral versus cutaneous peripheral nerves in the mouse

Journal article


Publication Details

Author(s): de Col R, Meßlinger K, Hoffmann T
Journal: Journal of Neuroscience Research
Publication year: 2018
Volume: 96
Journal issue: 8
Pages range: 1398-1405
ISSN: 0360-4012


Abstract

Cutaneous afferent nerves convey sensory information from the external, visceral nerves from the internal environment. The saphenous nerve arising from lumbar dorsal root ganglia and the vagus nerve originating in the nodosum ganglia are prototypic examples of such cutaneous and visceral nerves. Despite a common sensory role, these two nerves have distinct embryonic origin and vary in neuropeptide expression. Because of their distinct physiological roles, it is plausible that they differ also in conductive properties. We have tested calcitonin gene-related peptide (CGRP) release in these nerves in response to electrical and chemical stimulation. Electrical stimulation at 3, 6, and 9 Hz increased the release in saphenous but not vagus nerves, with 6 Hz being the most potent stimulus. Similarly, both capsaicin and a depolarizing solution of 60 mM KCl evoked CGRP release in saphenous but not vagus nerves. Simultaneous recording of the superimposed (compound) action potentials of these nerves revealed that only saphenous nerves exhibit a progressive and marked activity-dependent slowing of conduction velocity in response to electrical stimulation at 3, 6, and 9 Hz (30%, 44%, and 50%, respectively). Capsaicin caused an unexpected decrease in conduction latency (i.e., speeding) in contrast to the slowing seen in other nerves. Exposure of axons to 1 µM TTX rapidly blocked conduction in all nerves. Together our results demonstrate that vagus and saphenous primary afferents reveal different activation and conductive properties, presumably correlating their particular physiological roles in transmitting sensory signals. © 2018 Wiley Periodicals, Inc.


FAU Authors / FAU Editors

de Col, Roberto Dr.
Lehrstuhl für Physiologie
Hoffmann, Tal PD Dr.
Lehrstuhl für Physiologie
Meßlinger, Karl Prof. Dr.
Professur für Physiologie


How to cite

APA:
de Col, R., Meßlinger, K., & Hoffmann, T. (2018). Differential conduction and CGRP release in visceral versus cutaneous peripheral nerves in the mouse. Journal of Neuroscience Research, 96(8), 1398-1405. https://dx.doi.org/10.1002/jnr.24255

MLA:
de Col, Roberto, Karl Meßlinger, and Tal Hoffmann. "Differential conduction and CGRP release in visceral versus cutaneous peripheral nerves in the mouse." Journal of Neuroscience Research 96.8 (2018): 1398-1405.

BibTeX: 

Last updated on 2019-25-02 at 09:53