To NET or not to NET: current opinions and state of the science regarding the formation of neutrophil extracellular traps

Journal article
(Review article)


Publication Details

Author(s): Boeltz S, Amini P, Anders HJ, Andrade F, Bilyy R, Chatfield S, Cichon I, Clancy DM, Desai J, Dumych T, Dwivedi N, Gordon RA, Hahn J, Hidalgo A, Hoffmann M, Kaplan MJ, Knight JS, Kolaczkowska E, Kubes P, Leppkes M, Manfredi AA, Martin SJ, Maueröder C, Maugeri N, Mitroulis I, Munoz LE, Nakazawa D, Neeli I, Nizet V, Pieterse E, Radic MZ, Reinwald C, Ritis K, Rovere-Querini P, Santocki M, Schauer C, Schett G, Shlomchik MJ, Simon HU, Skendros P, Stojkov D, Vandenabeele P, Vanden Berghe T, Van Der Vlag J, Vitkov L, Von Koeckritz-Blickwede M, Yousefi S, Zarbock A, Herrmann M
Journal: Cell Death and Differentiation
Publication year: 2019
Volume: 26
Journal issue: 3
Pages range: 395-408
ISSN: 1350-9047


Abstract

Since the discovery and definition of neutrophil extracellular traps (NETs) 14 years ago, numerous characteristics and physiological functions of NETs have been uncovered. Nowadays, the field continues to expand and novel mechanisms that orchestrate formation of NETs, their previously unknown properties, and novel implications in disease continue to emerge. The abundance of available data has also led to some confusion in the NET research community due to contradictory results and divergent scientific concepts, such as pro- and anti-inflammatory roles in pathologic conditions, demarcation from other forms of cell death, or the origin of the DNA that forms the NET scaffold. Here, we present prevailing concepts and state of the science in NET-related research and elaborate on open questions and areas of dispute.


FAU Authors / FAU Editors

Hahn, Jonas
Medizinische Klinik 3 - Rheumatologie und Immunologie
Herrmann, Martin Prof. Dr.
Medizinische Klinik 3 - Rheumatologie und Immunologie
Medizinische Klinik 3 - Rheumatologie und Immunologie
Maueröder, Christian
Medizinische Klinik 3 - Rheumatologie und Immunologie
Reinwald, Christiane
Medizinische Klinik 3 - Rheumatologie und Immunologie
Schett, Georg Prof. Dr. med.
Lehrstuhl für Innere Medizin III


External institutions
Brigham and Women's Hospital (BWH)
Danylo Halytsky Lviv National Medical University / Львiвський Національний Медичний Унiверситет iм. Данила Галицького
Democritus University of Thrace (DUTH) / Δημοκρίτειο Πανεπιστήμιο Θράκης
Jagiellonian University / Uniwersytet Jagielloński (UJ)
Johns Hopkins University
Klinikum der Universität München (Großhadern und Innenstadt)
Radboud University Nijmegen
Spanish National Center for Cardiovascular Research / Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
Stiftung Tierärztliche Hochschule Hannover (TiHo)
Trinity College Dublin
Universität Bern
Universität Salzburg (Paris Lodron Universität Salzburg)
Università Vita-Salute San Raffaele (UniSR)
Universiteit Gent (UGent) / Ghent University
University of Calgary
University of California, San Diego
University of Michigan
University of Pittsburgh
University of Tennessee (UTK)
US National Institutes of Health (NIH)
Walter and Eliza Hall Institute of Medical Research (WEHI)
Westfälische Wilhelms-Universität (WWU) Münster


How to cite

APA:
Boeltz, S., Amini, P., Anders, H.-J., Andrade, F., Bilyy, R., Chatfield, S.,... Herrmann, M. (2019). To NET or not to NET: current opinions and state of the science regarding the formation of neutrophil extracellular traps. Cell Death and Differentiation, 26(3), 395-408. https://dx.doi.org/10.1038/s41418-018-0261-x

MLA:
Boeltz, Sebastian, et al. "To NET or not to NET: current opinions and state of the science regarding the formation of neutrophil extracellular traps." Cell Death and Differentiation 26.3 (2019): 395-408.

BibTeX: 

Last updated on 2019-26-03 at 10:08