To NET or not to NET: current opinions and state of the science regarding the formation of neutrophil extracellular traps

Boeltz S, Amini P, Anders HJ, Andrade F, Bilyy R, Chatfield S, Cichon I, Clancy DM, Desai J, Dumych T, Dwivedi N, Gordon RA, Hahn J, Hidalgo A, Hoffmann M, Kaplan MJ, Knight JS, Kolaczkowska E, Kubes P, Leppkes M, Manfredi AA, Martin SJ, Maueröder C, Maugeri N, Mitroulis I, Munoz LE, Nakazawa D, Neeli I, Nizet V, Pieterse E, Radic MZ, Reinwald C, Ritis K, Rovere-Querini P, Santocki M, Schauer C, Schett G, Shlomchik MJ, Simon HU, Skendros P, Stojkov D, Vandenabeele P, Vanden Berghe T, Van Der Vlag J, Vitkov L, Von Koeckritz-Blickwede M, Yousefi S, Zarbock A, Herrmann M (2019)

Publication Type: Journal article, Review article

Publication year: 2019

Journal

Book Volume: 26

Pages Range: 395-408

Journal Issue: 3

DOI: 10.1038/s41418-018-0261-x

Abstract

Since the discovery and definition of neutrophil extracellular traps (NETs) 14 years ago, numerous characteristics and physiological functions of NETs have been uncovered. Nowadays, the field continues to expand and novel mechanisms that orchestrate formation of NETs, their previously unknown properties, and novel implications in disease continue to emerge. The abundance of available data has also led to some confusion in the NET research community due to contradictory results and divergent scientific concepts, such as pro- and anti-inflammatory roles in pathologic conditions, demarcation from other forms of cell death, or the origin of the DNA that forms the NET scaffold. Here, we present prevailing concepts and state of the science in NET-related research and elaborate on open questions and areas of dispute.

Authors with CRIS profile

Involved external institutions

Trinity College Dublin Ireland (IE) University of California, San Diego United States (USA) (US) Brigham and Women's Hospital (BWH) United States (USA) (US) University of Pittsburgh United States (USA) (US) Università Vita-Salute San Raffaele (UniSR) Italy (IT) Klinikum der Universität München (Großhadern und Innenstadt) Germany (DE) Universiteit Gent (UGent) / Ghent University Belgium (BE) Walter and Eliza Hall Institute of Medical Research (WEHI) Australia (AU) Universität Bern Switzerland (CH) University of Tennessee (UTK) United States (USA) (US) Jagiellonian University / Uniwersytet Jagielloński (UJ) Poland (PL) Danylo Halytsky Lviv National Medical University / Львiвський Національний Медичний Унiверситет iм. Данила Галицького Ukraine (UA) Radboud University Nijmegen Netherlands (NL) US National Institutes of Health (NIH) United States (USA) (US) Democritus University of Thrace (DUTH) / Δημοκρίτειο Πανεπιστήμιο Θράκης Greece (GR) University of Calgary Canada (CA) Spanish National Center for Cardiovascular Research / Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) Spain (ES) University of Michigan United States (USA) (US) Johns Hopkins University (JHU) United States (USA) (US) Stiftung Tierärztliche Hochschule Hannover (TiHo) Germany (DE) Universität Salzburg (Paris Lodron Universität Salzburg) Austria (AT) Westfälische Wilhelms-Universität (WWU) Münster Germany (DE)

How to cite

APA:

Boeltz, S., Amini, P., Anders, H.-J., Andrade, F., Bilyy, R., Chatfield, S.,... Herrmann, M. (2019). To NET or not to NET: current opinions and state of the science regarding the formation of neutrophil extracellular traps. Cell Death and Differentiation, 26(3), 395-408. https://dx.doi.org/10.1038/s41418-018-0261-x

MLA:

Boeltz, Sebastian, et al. "To NET or not to NET: current opinions and state of the science regarding the formation of neutrophil extracellular traps." Cell Death and Differentiation 26.3 (2019): 395-408.

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