Piwi-like 1 protein expression is a prognostic factor for renal cell carcinoma patients

Journal article


Publication Details

Author(s): Stoehr CG, Steffens S, Polifka I, Jung R, Kahlmeyer A, Ivanyi P, Weber F, Hartmann A, Wullich B, Wach S, Taubert H
Journal: Scientific Reports
Publication year: 2019
Volume: 9
ISSN: 2045-2322


Abstract

The Piwi-like genes belong to the Argonaute gene family and are conserved in plants, animals and humans. In addition to their essential role in the germ line and as stem cell-associated genes, Piwi-like proteins play a role in different cancer types but have yet to be studied in renal cell carcinoma (RCC). We investigated tissue micro arrays (TMAs) with tumor samples of two independent cohorts of RCC patients (N = 265 and N = 345); we used immunohistochemistry to assess the protein expression of Piwi-like 1. Applying an immunoreactive score (IRS), we found Piwi-like 1 positivity (IRS > 0) in 28.3% and 14.8% of the tumors in cohorts 1 and 2, respectively. Piwi-like 1 positivity was correlated with Fuhrman grade, tumor stage and the presence of distant metastasis (P < 0.005). Moreover, in univariate and multivariate analyses (adjusted to Fuhrman grade and tumor stage), Piwi-like 1 positivity was associated with a shorter cancer-specific survival in the patients in the second cohort. In addition, Piwi-like 1 expression allowed to further distinguish the RCC patients with high Fuhrman grade, high tumor stage, distant metastasis or high pre-operative levels of C-reactive protein, as Piwi-like 1 positivity was associated with a shorter cancer-specific survival in both cohorts. Our data encourage further investigations to enlighten the role of Piwi-like 1 and its function as a marker of poor prognosis in RCC patients.


FAU Authors / FAU Editors

Hartmann, Arndt Prof. Dr. med.
Taubert, Helge Prof. Dr. rer. nat.
Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie
Polifka, Iris Dr. med.
Pathologisches Institut
Urologische Klinik
Wullich, Bernd Prof. Dr.
Lehrstuhl für Urologie


External institutions with authors

Hannover Medical School / Medizinische Hochschule Hannover (MHH)
Universität Regensburg
Universitätsklinikum Münster


How to cite

APA:
Stoehr, C.G., Steffens, S., Polifka, I., Jung, R., Kahlmeyer, A., Ivanyi, P.,... Taubert, H. (2019). Piwi-like 1 protein expression is a prognostic factor for renal cell carcinoma patients. Scientific Reports, 9. https://dx.doi.org/10.1038/s41598-018-38254-3

MLA:
Stoehr, C. G., et al. "Piwi-like 1 protein expression is a prognostic factor for renal cell carcinoma patients." Scientific Reports 9 (2019).

BibTeX: 

Last updated on 2019-28-02 at 06:14