Potential of Sodium MRI as a Biomarker for Neurodegeneration and Neuroinflammation in Multiple Sclerosis

Journal article
(Review article)


Publication Details

Author(s): Huhn K, Engelhorn T, Linker RA, Nagel AM
Journal: Frontiers in Neurology
Publication year: 2019
Volume: 10
Pages range: 84
ISSN: 1664-2295


Abstract

In multiple sclerosis (MS), experimental and ex vivo studies indicate that pathologic intra-and extracellular sodium accumulation may play a pivotal role in inflammatory as well as neurodegenerative processes. Yet, in vivo assessment of sodium in the microenvironment is hard to achieve. Here, sodium magnetic resonance imaging ((NaMRI)-Na-23) with its non-invasive properties offers a unique opportunity to further elucidate the effects of sodium disequilibrium in MS pathology in vivo in addition to regular proton based MRI. However, unfavorable physical properties and low in vivo concentrations of sodium ions resulting in low signal-to-noise-ratio (SNR) as well as low spatial resolution resulting in partial volume effects limited the application of (NaMRI)-Na-23. With the recent advent of high-field MRI scanners and more sophisticated sodium MRI acquisition techniques enabling better resolution and higher SNR, (NaMRI)-Na-23 revived. These studies revealed pathologic total sodium concentrations in MS brains now even allowing for the (partial) differentiation of intra-and extracellular sodium accumulation. Within this review we (1) demonstrate the physical basis and imaging techniques of (NaMRI)-Na-23 and (2) analyze the present and future clinical application of (NaMRI)-Na-23 focusing on the field of MS thus highlighting its potential as biomarker for neuroinflammation and -degeneration.


FAU Authors / FAU Editors

Nagel, Armin Michael Prof. Dr.
Professur für metabolische und funktionelle MR-Bildgebung


External institutions with authors

Universität Regensburg


How to cite

APA:
Huhn, K., Engelhorn, T., Linker, R.A., & Nagel, A.M. (2019). Potential of Sodium MRI as a Biomarker for Neurodegeneration and Neuroinflammation in Multiple Sclerosis. Frontiers in Neurology, 10, 84. https://dx.doi.org/10.3389/fneur.2019.00084

MLA:
Huhn, Konstantin, et al. "Potential of Sodium MRI as a Biomarker for Neurodegeneration and Neuroinflammation in Multiple Sclerosis." Frontiers in Neurology 10 (2019): 84.

BibTeX: 

Last updated on 2019-01-07 at 09:21