Health-related quality of life in people with type 2 diabetes participating in the LEADER trial

Nauck MA, Buse JB, Mann J, Pocock S, Bosch-Traberg H, Frimer-Larsen H, Ye Q, Gray A (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Diabetes Obesity & Metabolism Wiley-Blackwell

Book Volume: 21

Pages Range: 525-532

Journal Issue: 3

DOI: 10.1111/dom.13547

Abstract

Aims To assess health-related quality of life (HRQoL) in people with type 2 diabetes (T2D) participating in the LEADER cardiovascular outcomes trial using the five-dimension European Quality of Life questionnaire (EQ-5D). Materials and methods The EQ-5D was administered every 12 months in a subset of patients from Canada, Denmark, Germany, Ireland, Italy, Netherlands, Spain, Sweden, the United Kingdom and the United States. We compared changes in utility index scores and visual analogue scale (VAS) scores from baseline to 36 months in participants treated with liraglutide and placebo. We also assessed which complications had the greatest impact on quality of life. Results At 36 months, less deterioration in EQ-5D utility index score was seen in the liraglutide group (-0.058) than in the placebo group (-0.082; estimated treatment difference [ETD] 0.023, 95% confidence interval [CI] 0.004;0.043; P = 0.020). A smaller decrease in EQ-5D VAS score was also demonstrated in the liraglutide group (-3.51) vs. the placebo group (-5.45; ETD 1.94, 95% CI 0.32;3.57; P = 0.019). The benefits of liraglutide treatment compared with placebo were driven primarily by shifts in the domains of mobility and self-care. The most influential events contributing to poorer HRQoL were stroke, heart failure, malignant neoplasm and confirmed hypoglycaemia. Conclusions Liraglutide demonstrated a modest but significant benefit in patient-reported health status using the EQ-5D, compared with placebo. This benefit may be of clinical relevance and requires further study.

Involved external institutions

Ruhr-Universität Bochum (RUB) DE Germany (DE) London School of Hygiene and Tropical Medicine GB United Kingdom (GB) Novo Nordisk A/S DK Denmark (DK) University of North Carolina at Chapel Hill US United States (USA) (US) University of Oxford GB United Kingdom (GB)

How to cite

APA:

Nauck, M.A., Buse, J.B., Mann, J., Pocock, S., Bosch-Traberg, H., Frimer-Larsen, H.,... Gray, A. (2019). Health-related quality of life in people with type 2 diabetes participating in the LEADER trial. Diabetes Obesity & Metabolism, 21(3), 525-532. https://dx.doi.org/10.1111/dom.13547

MLA:

Nauck, Michael A., et al. "Health-related quality of life in people with type 2 diabetes participating in the LEADER trial." Diabetes Obesity & Metabolism 21.3 (2019): 525-532.

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