Long-term stable measurement phantoms for magnetic particle imaging

Woeckel L, Wells J, Kosch O, Lyer S, Alexiou C, Gruettner C, Wiekhorst F, Dutz S (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Journal of Magnetism and Magnetic Materials Elsevier

Book Volume: 471

Pages Range: 1-7

DOI: 10.1016/j.jmmm.2018.09.012

Abstract

Magnetic particle imaging (MPI) is a tomographic imaging method to determine the spatial distribution of magnetic nanoparticles (MNP) within a defined volume. To evaluate the imaging capabilities of existing MPI scanners, their sensitivity and image resolution limits have to be analyzed. Therefore, precisely defined structures (phantoms) with various tracer concentrations are required to enable comparative studies between existing MPI systems. To support the development of capable MPI phantoms, we developed a method to incorporate different commercially available MNP into a long-term stable synthetic polymer with an iron concentration of up to 200 mmol/l. The properties of each type of polymer matrix embedded MNP were tested by magnetic particle spectroscopy (MPS). For shaping the particle loaded polymer to a phantom, we used 3-D printed molds with a structure cross section of 2 x 2 mm(2). The particle loads within the phantoms were then imaged using MPI. The particle-loaded polymer is very suitable for preparation of measurement phantoms that could be visualized by MPI. Repeated shore hardness and MPS measurements up to one year did not reveal any changes in the mechanical and magnetic properties of the used material. In conclusion, we developed long-term stable measurement phantoms for magnetic particle imaging. Further work will focus on more detailed particle loaded structures in phantoms and water based polymers with a more homogeneous particle distribution.

Authors with CRIS profile

Stefan Lyer Department of Otorhinolaryngology – Head and Neck Surgery Christoph Alexiou Professur für Nanomedizin

Involved external institutions

Technische Universität Ilmenau DE Germany (DE) Physikalisch-Technische Bundesanstalt (PTB) DE Germany (DE) micromod Partikeltechnologie GmbH DE Germany (DE)

How to cite

APA:

Woeckel, L., Wells, J., Kosch, O., Lyer, S., Alexiou, C., Gruettner, C.,... Dutz, S. (2019). Long-term stable measurement phantoms for magnetic particle imaging. Journal of Magnetism and Magnetic Materials, 471, 1-7. https://dx.doi.org/10.1016/j.jmmm.2018.09.012

MLA:

Woeckel, Lucas, et al. "Long-term stable measurement phantoms for magnetic particle imaging." Journal of Magnetism and Magnetic Materials 471 (2019): 1-7.

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