c-Rel is a cell cycle modulator in human melanoma cells

Journal article

Publication Details

Author(s): Priebe MK, Dewert N, Amschler K, Erpenbeck L, Heinzerling L, Schoen MP, Seitz CS, Lorenz VN
Journal: Experimental Dermatology
Publication year: 2019
Volume: 28
Journal issue: 2
Pages range: 121-128
ISSN: 0906-6705


Melanoma progression and resistance to therapy are associated with faulty regulation of signalling molecules including the central transcription factor NF-kappa B. Increased expression of the c-Rel subunit of NF-kappa B has been described in progressing melanoma, though mechanistic implications of this upregulation remain unclear. To elucidate the functional role of c-Rel in melanoma biology, we have assessed its expression in human melanoma as well as in melanoma cell lines. Suppression of c-Rel expression in four melanoma cell lines resulted in reduced growth and altered cell cycle regulation, namely G2/M and polyploid phase induction. Moreover, mitotic spindle morphology was profoundly altered in three of the cell lines with a predominance of monopolar structures. These findings suggest that c-Rel is involved in G2/M phase regulation, prevention of polyploidy and, consequently, chromosomal stability. Our results highlight a novel tumor-promoting function of c-Rel in human melanoma cells through governing cell cycle regulation.

FAU Authors / FAU Editors

Heinzerling, Lucie Prof. Dr.

External institutions with authors

Georg-August-Universität Göttingen

How to cite

Priebe, M.K., Dewert, N., Amschler, K., Erpenbeck, L., Heinzerling, L., Schoen, M.P.,... Lorenz, V.N. (2019). c-Rel is a cell cycle modulator in human melanoma cells. Experimental Dermatology, 28(2), 121-128. https://dx.doi.org/10.1111/exd.13848

Priebe, Marie K., et al. "c-Rel is a cell cycle modulator in human melanoma cells." Experimental Dermatology 28.2 (2019): 121-128.


Last updated on 2019-06-03 at 10:23