c-Rel is a cell cycle modulator in human melanoma cells

Priebe MK, Dewert N, Amschler K, Erpenbeck L, Heinzerling L, Schoen MP, Seitz CS, Lorenz VN (2019)


Publication Type: Journal article

Publication year: 2019

Journal

Book Volume: 28

Pages Range: 121-128

Journal Issue: 2

DOI: 10.1111/exd.13848

Abstract

Melanoma progression and resistance to therapy are associated with faulty regulation of signalling molecules including the central transcription factor NF-kappa B. Increased expression of the c-Rel subunit of NF-kappa B has been described in progressing melanoma, though mechanistic implications of this upregulation remain unclear. To elucidate the functional role of c-Rel in melanoma biology, we have assessed its expression in human melanoma as well as in melanoma cell lines. Suppression of c-Rel expression in four melanoma cell lines resulted in reduced growth and altered cell cycle regulation, namely G2/M and polyploid phase induction. Moreover, mitotic spindle morphology was profoundly altered in three of the cell lines with a predominance of monopolar structures. These findings suggest that c-Rel is involved in G2/M phase regulation, prevention of polyploidy and, consequently, chromosomal stability. Our results highlight a novel tumor-promoting function of c-Rel in human melanoma cells through governing cell cycle regulation.

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APA:

Priebe, M.K., Dewert, N., Amschler, K., Erpenbeck, L., Heinzerling, L., Schoen, M.P.,... Lorenz, V.N. (2019). c-Rel is a cell cycle modulator in human melanoma cells. Experimental Dermatology, 28(2), 121-128. https://dx.doi.org/10.1111/exd.13848

MLA:

Priebe, Marie K., et al. "c-Rel is a cell cycle modulator in human melanoma cells." Experimental Dermatology 28.2 (2019): 121-128.

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