Electrospun patterned porous scaffolds for the support of ovarian follicles growth: a feasibility study

Journal article


Publication Details

Author(s): Liverani L, Raffel N, Amir F, Preis A, Hoffmann I, Boccaccini AR, Beckmann M, Dittrich R
Journal: Scientific Reports
Publication year: 2019
Volume: 9
ISSN: 2045-2322


Abstract

Recently, the interest of the scientific community is focused on the application of tissue engineering approach for the fertility restoration. In this paper innovative patterned electrospun fibrous scaffolds were fabricated and used as 3D system for porcine follicles culture. The obtained scaffolds demonstrated to be a suitable support which did not alter or interfere with the typical spherical follicles morphology. The fibrillar structure of the scaffolds mimics the morphology of the healthy native tissue. The use of porcine follicles implied many advantages respect to the use of mouse model. Relevant results showed that more than the scaffold pattern and struts dimension, the selection of proper biomaterials improve the follicles adhesion and development.


FAU Authors / FAU Editors

Amir, Fattahi
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Beckmann, Matthias Prof. Dr.
Lehrstuhl für Geburtshilfe und Frauenheilkunde
Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Dittrich, Ralf Prof. Dr.
Professur für Experimentelle Reproduktionsmedizin
Liverani, Liliana Dr.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Raffel, Nathalie
Frauenklinik


How to cite

APA:
Liverani, L., Raffel, N., Amir, F., Preis, A., Hoffmann, I., Boccaccini, A.R.,... Dittrich, R. (2019). Electrospun patterned porous scaffolds for the support of ovarian follicles growth: a feasibility study. Scientific Reports, 9. https://dx.doi.org/10.1038/s41598-018-37640-1

MLA:
Liverani, Liliana, et al. "Electrospun patterned porous scaffolds for the support of ovarian follicles growth: a feasibility study." Scientific Reports 9 (2019).

BibTeX: 

Last updated on 2019-28-02 at 06:24