Electrospun patterned porous scaffolds for the support of ovarian follicles growth: a feasibility study

Liverani L, Amir F, Raffel N, Preis A, Hoffmann I, Boccaccini AR, Beckmann M, Dittrich R (2019)

Publication Type: Journal article, Original article

Publication year: 2019

Journal

Scientific Reports Nature Publishing Group: Open Access Journals - Option B

Book Volume: 9

Article Number: 1150

Journal Issue: 1

DOI: 10.1038/s41598-018-37640-1

Abstract

Recently, the interest of the scientific community is focused on the application of tissue engineering approach for the fertility restoration. In this paper innovative patterned electrospun fibrous scaffolds were fabricated and used as 3D system for porcine follicles culture. The obtained scaffolds demonstrated to be a suitable support which did not alter or interfere with the typical spherical follicles morphology. The fibrillar structure of the scaffolds mimics the morphology of the healthy native tissue. The use of porcine follicles implied many advantages respect to the use of mouse model. Relevant results showed that more than the scaffold pattern and struts dimension, the selection of proper biomaterials improve the follicles adhesion and development.

Authors with CRIS profile

Liliana Liverani Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Fattahi Amir Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Nathalie Bleisinger Department of Obstetrics and Gynaecology Alexander Preis Lehrstuhl für Fertigungsautomatisierung und Produktionssystematik Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Matthias Beckmann Lehrstuhl für Geburtshilfe und Frauenheilkunde Ralf Dittrich Professur für Experimentelle Reproduktionsmedizin

How to cite

APA:

Liverani, L., Amir, F., Raffel, N., Preis, A., Hoffmann, I., Boccaccini, A.R.,... Dittrich, R. (2019). Electrospun patterned porous scaffolds for the support of ovarian follicles growth: a feasibility study. Scientific Reports, 9(1). https://dx.doi.org/10.1038/s41598-018-37640-1

MLA:

Liverani, Liliana, et al. "Electrospun patterned porous scaffolds for the support of ovarian follicles growth: a feasibility study." Scientific Reports 9.1 (2019).

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