Soluble ST2 regulation by rhinovirus and 25(OH)-vitamin D3 in the blood of asthmatic children

Journal article

Publication Details

Author(s): Haag P, Sharma H, Rauh M, Zimmermann T, Vuorinen T, Papadopoulos NG, Weiss ST, Finotto S
Journal: Clinical and Experimental Immunology
Publication year: 2018
Volume: 193
Journal issue: 2
Pages range: 207-220
ISSN: 0009-9104


Paediatric asthma exacerbations are often caused by rhinovirus (RV). Moreover, 25(OH)-vitamin D3 (VitD3) deficiency during infancy was found associated with asthma. Here, we investigated the innate immune responses to RV and their possible modulation by 25(OH)-VitD3 serum levels in a preschool cohort of children with and without asthma. The innate lymphoid cell type 2 (ILC2)-associated marker, ST2, was found up-regulated in the blood cells of asthmatic children with low serum levels of 25(OH)-VitD3 in the absence of RV in their airways. Furthermore, in blood cells from control and asthmatic children with RV in their airways, soluble (s) ST2 (sST2) protein was found reduced. Asthmatic children with low 25(OH)-VitD3 in serum and with RV in vivo in their airways at the time of the analysis had the lowest sST2 protein levels in the peripheral blood compared to control children without RV and high levels of 25(OH)-VitD3. Amphiregulin (AREG), another ILC2-associated marker, was found induced in the control children with RV in their airways and low serum levels of 25(OH)-VitD3. In conclusion, the anti-inflammatory soluble form of ST2, also known as sST2, in serum correlated directly with interleukin (IL)-33 in the airways of asthmatic children. Furthermore, RV colonization in the airways and low serum levels of 25(OH)-VitD3 were found to be associated with down-regulation of sST2 in serum in paediatric asthma. These data indicate a counter-regulatory role of 25(OH)-VitD3 on RV-induced down-regulation of serum sST2 in paediatric asthma, which is relevant for the therapy of this disease.

FAU Authors / FAU Editors

Haag, Patricia
Professur für Molekulare Pneumologie
Rauh, Manfred Prof. Dr.
Kinder- und Jugendklinik
Zimmermann, Theodor apl. Prof. Dr.
Medizinische Fakultät

External institutions with authors

National and Kapodistrian University of Athens
Partners HealthCare
University of Turku / Turun yliopisto

How to cite

Haag, P., Sharma, H., Rauh, M., Zimmermann, T., Vuorinen, T., Papadopoulos, N.G.,... Finotto, S. (2018). Soluble ST2 regulation by rhinovirus and 25(OH)-vitamin D3 in the blood of asthmatic children. Clinical and Experimental Immunology, 193(2), 207-220.

Haag, Patricia, et al. "Soluble ST2 regulation by rhinovirus and 25(OH)-vitamin D3 in the blood of asthmatic children." Clinical and Experimental Immunology 193.2 (2018): 207-220.


Last updated on 2019-26-02 at 17:08