International Clinical Practice Guidelines for Sarcopenia (ICFSR): Screening, Diagnosis and Management

Journal article

Publication Details

Author(s): Dent E, Morley JE, Cruz-Jentoft AJ, Arai H, Kritchevsky SB, Guralnik J, Bauer JM, Pahor M, Clark BC, Cesari M, Ruiz J, Sieber C, Aubertin-Leheudre M, Waters DL, Visvanathan R, Landi F, Villareal DT, Fielding R, Won CW, Theou O, Martin FC, Dong B, Woo J, Flicker L, Ferrucci L, Merchant RA, Cao L, Cederholm T, Ribeiro SML, Rodriguez-Manas L, Anker SD, Lundy J, Gutierrez Robledo LM, Bautmans I, Aprahamian I, Schols JMGA, Izquierdo M, Vellas B
Journal: The journal of nutrition, health & aging
Publication year: 2018
Volume: 22
Journal issue: 10
Pages range: 1148-1161
ISSN: 1279-7707
eISSN: 1760-4788


ObjectivesSarcopenia, defined as an age-associated loss of skeletal muscle function and muscle mass, occurs in approximately 6 - 22 % of older adults. This paper presents evidence-based clinical practice guidelines for screening, diagnosis and management of sarcopenia from the task force of the International Conference on Sarcopenia and Frailty Research (ICSFR).MethodsTo develop the guidelines, we drew upon the best available evidence from two systematic reviews paired with consensus statements by international working groups on sarcopenia. Eight topics were selected for the recommendations: (i) defining sarcopenia; (ii) screening and diagnosis; (iii) physical activity prescription; (iv) protein supplementation; (v) vitamin D supplementation; (vi) anabolic hormone prescription; (vii) medications under development; and (viii) research. The ICSFR task force evaluated the evidence behind each topic including the quality of evidence, the benefitharm balance of treatment, patient preferences/values, and cost-effectiveness. Recommendations were graded as either strong or conditional (weak) as per the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach. Consensus was achieved via one face-to-face workshop and a modified Delphi process.RecommendationsWe make a conditional recommendation for the use of an internationally accepted measurement tool for the diagnosis of sarcopenia including the EWGSOP and FNIH definitions, and advocate for rapid screening using gait speed or the SARC-F. To treat sarcopenia, we strongly recommend the prescription of resistance-based physical activity, and conditionally recommend protein supplementation/a protein-rich diet. No recommendation is given for Vitamin D supplementation or for anabolic hormone prescription. There is a lack of robust evidence to assess the strength of other treatment options.

FAU Authors / FAU Editors

Sieber, Cornel Prof. Dr.
Lehrstuhl für Innere Medizin (Geriatrie)

External institutions with authors

Centre Hospitalier Universitaire (CHU) de Toulouse
Charité - Universitätsmedizin Berlin
Faculdade de Medicina de Jundiaí (FMJ)
Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hospital Universitario de Getafe
Hospital Universitario Ramón y Cajal
Kyung Hee University
Maastricht University
Michael E. DeBakey VA Medical Center
National Center for Geriatrics and Gerontology
National Institute on Aging (NIA)
National University Health System (NUHS)
Ohio University
Perry County Memorial Hospital
Saint Louis University (SLU)
Sichuan University (SCU) / 四川大学
The Chinese University of Hong Kong (CUHK)
Torrens University Australia
Tufts University
Universidad Pública de Navarra
University of Adelaide
University of Florida
University of Maryland
University of Miami
University of Otago
University of São Paulo / Universidade de São Paulo (USP)
University of Western Australia (UWA)
Uppsala University
Vrije Universiteit Brussel
Wake Forest University

How to cite

Dent, E., Morley, J.E., Cruz-Jentoft, A.J., Arai, H., Kritchevsky, S.B., Guralnik, J.,... Vellas, B. (2018). International Clinical Practice Guidelines for Sarcopenia (ICFSR): Screening, Diagnosis and Management. The journal of nutrition, health & aging, 22(10), 1148-1161.

Dent, E., et al. "International Clinical Practice Guidelines for Sarcopenia (ICFSR): Screening, Diagnosis and Management." The journal of nutrition, health & aging 22.10 (2018): 1148-1161.


Last updated on 2019-28-03 at 09:08