International Clinical Practice Guidelines for Sarcopenia (ICFSR): Screening, Diagnosis and Management

Dent E, Morley JE, Cruz-Jentoft AJ, Arai H, Kritchevsky SB, Guralnik J, Bauer JM, Pahor M, Clark BC, Cesari M, Ruiz J, Sieber C, Aubertin-Leheudre M, Waters DL, Visvanathan R, Landi F, Villareal DT, Fielding R, Won CW, Theou O, Martin FC, Dong B, Woo J, Flicker L, Ferrucci L, Merchant RA, Cao L, Cederholm T, Ribeiro SML, Rodriguez-Manas L, Anker SD, Lundy J, Gutierrez Robledo LM, Bautmans I, Aprahamian I, Schols JMGA, Izquierdo M, Vellas B (2018)

Publication Status: Published

Publication Type: Journal article

Publication year: 2018

Journal

Publisher: SPRINGER FRANCE

Book Volume: 22

Pages Range: 1148-1161

Journal Issue: 10

DOI: 10.1007/s12603-018-1139-9

Abstract

ObjectivesSarcopenia, defined as an age-associated loss of skeletal muscle function and muscle mass, occurs in approximately 6 - 22 % of older adults. This paper presents evidence-based clinical practice guidelines for screening, diagnosis and management of sarcopenia from the task force of the International Conference on Sarcopenia and Frailty Research (ICSFR).MethodsTo develop the guidelines, we drew upon the best available evidence from two systematic reviews paired with consensus statements by international working groups on sarcopenia. Eight topics were selected for the recommendations: (i) defining sarcopenia; (ii) screening and diagnosis; (iii) physical activity prescription; (iv) protein supplementation; (v) vitamin D supplementation; (vi) anabolic hormone prescription; (vii) medications under development; and (viii) research. The ICSFR task force evaluated the evidence behind each topic including the quality of evidence, the benefitharm balance of treatment, patient preferences/values, and cost-effectiveness. Recommendations were graded as either strong or conditional (weak) as per the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach. Consensus was achieved via one face-to-face workshop and a modified Delphi process.RecommendationsWe make a conditional recommendation for the use of an internationally accepted measurement tool for the diagnosis of sarcopenia including the EWGSOP and FNIH definitions, and advocate for rapid screening using gait speed or the SARC-F. To treat sarcopenia, we strongly recommend the prescription of resistance-based physical activity, and conditionally recommend protein supplementation/a protein-rich diet. No recommendation is given for Vitamin D supplementation or for anabolic hormone prescription. There is a lack of robust evidence to assess the strength of other treatment options.

Authors with CRIS profile

Involved external institutions

Wake Forest University United States (USA) (US) University of Adelaide Australia (AU) University of Maryland United States (USA) (US) Kyung Hee University Korea, Republic of (KR) Tufts University United States (USA) (US) University of Otago New Zealand (NZ) Michael E. DeBakey VA Medical Center United States (USA) (US) University of Florida United States (USA) (US) Ohio University United States (USA) (US) Fondazione Policlinico Universitario Agostino Gemelli IRCCS Italy (IT) The Chinese University of Hong Kong (CUHK) China (CN) University of Miami United States (USA) (US) Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico Italy (IT) Sichuan University (SCU) / 四川大学 China (CN) Centre Hospitalier Universitaire (CHU) de Toulouse France (FR) National Institute on Aging (NIA) United States (USA) (US) National Center for Geriatrics and Gerontology Japan (JP) Faculdade de Medicina de Jundiaí (FMJ) Brazil (BR) Perry County Memorial Hospital United States (USA) (US) University of Western Australia (UWA) Australia (AU) Vrije Universiteit Brussel (VUB) Belgium (BE) Hospital Universitario de Getafe Spain (ES) National University Health System (NUHS) Singapore (SG) University of São Paulo / Universidade de São Paulo (USP) Brazil (BR) Maastricht University Netherlands (NL) Universidad Pública de Navarra Spain (ES) Saint Louis University (SLU) United States (USA) (US) Uppsala University Sweden (SE) Charité - Universitätsmedizin Berlin Germany (DE) Torrens University Australia Australia (AU) Hospital Universitario Ramón y Cajal Spain (ES)

How to cite

APA:

Dent, E., Morley, J.E., Cruz-Jentoft, A.J., Arai, H., Kritchevsky, S.B., Guralnik, J.,... Vellas, B. (2018). International Clinical Practice Guidelines for Sarcopenia (ICFSR): Screening, Diagnosis and Management. Journal of Nutrition, Health & Aging, 22(10), 1148-1161. https://dx.doi.org/10.1007/s12603-018-1139-9

MLA:

Dent, E., et al. "International Clinical Practice Guidelines for Sarcopenia (ICFSR): Screening, Diagnosis and Management." Journal of Nutrition, Health & Aging 22.10 (2018): 1148-1161.

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