Synthesis of new betulinic acid/betulin-derived dimers and hybrids with potent antimalarial and antiviral activities

Journal article


Publication Details

Author(s): Capci Karagoez A, Leidenberger M, Hahn F, Friedrich O, Hampel F, Marschall M, Kappes B, Tsogoeva S
Journal: Bioorganic & Medicinal Chemistry
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Publication year: 2019
Volume: 27
Journal issue: 1
Pages range: 110-115
ISSN: 0968-0896
Language: English


Abstract

Severe malaria and viral infections cause life-threatening diseases in millions of people worldwide every year. In search for effective bioactive hybrid molecules, which may possess improved properties compared to their parent compounds, a series of betulinic acid/betulin based dimer and hybrid compounds carrying ferrocene and/or artesunic acid moieties, was designed and, synthesized de novo. Furthermore, they were analyzed in vitro against malaria parasites (growth inhibition of 3D7-strain P. falciparum-infected erythrocytes) and human cytomegalovirus (HCMV). From this series of hybrids/dimers, the betulinic acid/betulin and artesunic acid hybrids 11 and 12 showed the most potent activities against P. falciparum and HCMV. On the strength of results, additive and/or synergistic effects between the natural or semisynthetic products, such as betulinic acid-/betulin- and artesunic acid-derived compounds, are suggested on the basis of putatively complex modes of antimicrobial action. This advantage may be taken into account in future drug development.


FAU Authors / FAU Editors

Capci Karagoez, Aysun
Professur für Organische Chemie
Friedrich, Oliver Prof. Dr. Dr.
Lehrstuhl für Medizinische Biotechnologie
Hahn, Friedrich
Professur für Virologie
Hampel, Frank Dr.
Lehrstuhl für Organische Chemie I
Kappes, Bärbel Prof. Dr.
Technische Fakultät
Leidenberger, Maria
Lehrstuhl für Medizinische Biotechnologie
Marschall, Manfred apl. Prof. Dr.
Medizinische Fakultät
Tsogoeva, Svetlana Prof. Dr.
Professur für Organische Chemie


How to cite

APA:
Capci Karagoez, A., Leidenberger, M., Hahn, F., Friedrich, O., Hampel, F., Marschall, M.,... Tsogoeva, S. (2019). Synthesis of new betulinic acid/betulin-derived dimers and hybrids with potent antimalarial and antiviral activities. Bioorganic & Medicinal Chemistry, 27(1), 110-115. https://dx.doi.org/10.1016/j.bmc.2018.11.018

MLA:
Capci Karagoez, Aysun, et al. "Synthesis of new betulinic acid/betulin-derived dimers and hybrids with potent antimalarial and antiviral activities." Bioorganic & Medicinal Chemistry 27.1 (2019): 110-115.

BibTeX: 

Last updated on 2019-21-07 at 07:27