Synthesis of new betulinic acid/betulin-derived dimers and hybrids with potent antimalarial and antiviral activities

Journal article


Publication Details

Author(s): Capci Karagöz A, Leidenberger M, Hahn F, Friedrich O, Hampel F, Marschall M, Kappes B, Tsogoeva S
Journal: Bioorganic & Medicinal Chemistry
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Publication year: 2019
Volume: 27
Journal issue: 1
Pages range: 110-115
ISSN: 0968-0896
Language: English


Abstract

Severe malaria and viral infections cause life-threatening diseases in millions of people worldwide every year. In search for effective bioactive hybrid molecules, which may possess improved properties compared to their parent compounds, a series of betulinic acid/betulin based dimer and hybrid compounds carrying ferrocene and/or artesunic acid moieties, was designed and, synthesized de novo. Furthermore, they were analyzed in vitro against malaria parasites (growth inhibition of 3D7-strain P. falciparum-infected erythrocytes) and human cytomegalovirus (HCMV). From this series of hybrids/dimers, the betulinic acid/betulin and artesunic acid hybrids 11 and 12 showed the most potent activities against P. falciparum and HCMV. On the strength of results, additive and/or synergistic effects between the natural or semisynthetic products, such as betulinic acid-/betulin- and artesunic acid-derived compounds, are suggested on the basis of putatively complex modes of antimicrobial action. This advantage may be taken into account in future drug development.


FAU Authors / FAU Editors

Capci Karagoez, Aysun
Professur für Organische Chemie
Friedrich, Oliver Prof. Dr. Dr.
Lehrstuhl für Medizinische Biotechnologie
Hahn, Friedrich
Professur für Virologie
Hampel, Frank Dr.
Kappes, Bärbel Prof. Dr.
Lehrstuhl für Organische Chemie I
Technische Fakultät
Leidenberger, Maria
Lehrstuhl für Medizinische Biotechnologie
Marschall, Manfred apl. Prof. Dr.
Medizinische Fakultät
Tsogoeva, Svetlana Prof. Dr.
Professur für Organische Chemie


How to cite

APA:
Capci Karagöz, A., Leidenberger, M., Hahn, F., Friedrich, O., Hampel, F., Marschall, M.,... Tsogoeva, S. (2019). Synthesis of new betulinic acid/betulin-derived dimers and hybrids with potent antimalarial and antiviral activities. Bioorganic & Medicinal Chemistry, 27(1), 110-115. https://dx.doi.org/10.1016/j.bmc.2018.11.018

MLA:
Capci Karagöz, Aysun, et al. "Synthesis of new betulinic acid/betulin-derived dimers and hybrids with potent antimalarial and antiviral activities." Bioorganic & Medicinal Chemistry 27.1 (2019): 110-115.

BibTeX: 

Last updated on 2019-15-02 at 10:53