In Vitro Endothelialization of Surface-Integrated Nanofiber Networks for Stretchable Blood Interfaces.

Weidenbacher L, Müller E, Guex AG, Zündel M, Schweizer P, Marina V, Adlhart C, Vejsadová L, Pauer R, Spiecker E, Maniura-Weber K, Ferguson SJ, Rossi RM, Rottmar M, Fortunato G (2019)

Publication Status: Published

Publication Type: Journal article

Publication year: 2019

Journal

ACS Applied Materials and Interfaces American Chemical Society

DOI: 10.1021/acsami.8b18121

Abstract

Despite major technological advances within the field of cardiovascular engineering, the risk of thromboembolic events on artificial surfaces in contact with blood remains a major challenge and limits the functionality of ventricular assist devices (VADs) during mid- or long-term therapy. Here, a biomimetic blood-material interface is created via a nanofiber-based approach that promotes the endothelialization capability of elastic silicone surfaces for next-generation VADs under elevated hemodynamic loads. A blend fiber membrane made of elastic polyurethane and low-thrombogenic poly(vinylidene fluoride- co-hexafluoropropylene) was partially embedded into the surface of silicone films. These blend membranes resist fundamental irreversible deformation of the internal structure and are stably attached to the surface, while also exhibiting enhanced antithrombotic properties when compared to bare silicone. The composite material supports the formation of a stable monolayer of endothelial cells within a pulsatile flow bioreactor, resembling the physiological in vivo situation in a VAD. The nanofiber surface modification concept thus presents a promising approach for the future design of advanced elastic composite materials that are particularly interesting for applications in contact with blood.

Authors with CRIS profile

Peter Schweizer Lehrstuhl für Werkstoffwissenschaften (Mikro- und Nanostrukturforschung) Erdmann Spiecker Lehrstuhl für Werkstoffwissenschaften (Mikro- und Nanostrukturforschung)

Additional Organisation(s)

Lehrstuhl für Werkstoffwissenschaften (Mikro- und Nanostrukturforschung) Graduiertenkolleg 1896/2 In situ Mikroskopie mit Elektronen, Röntgenstrahlen und Rastersonden Interdisziplinäres Zentrum, Center for Nanoanalysis and Electron Microscopy (CENEM)

How to cite

APA:

Weidenbacher, L., Müller, E., Guex, A.G., Zündel, M., Schweizer, P., Marina, V.,... Fortunato, G. (2019). In Vitro Endothelialization of Surface-Integrated Nanofiber Networks for Stretchable Blood Interfaces. ACS Applied Materials and Interfaces. https://dx.doi.org/10.1021/acsami.8b18121

MLA:

Weidenbacher, Lukas, et al. "In Vitro Endothelialization of Surface-Integrated Nanofiber Networks for Stretchable Blood Interfaces." ACS Applied Materials and Interfaces (2019).

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