Vascular Calcification in Chronic Kidney Disease: The Role of Inflammation

Journal article


Publication Details

Author(s): Benz K, Hilgers KF, Daniel C, Amann KU
Journal: International Journal of Nephrology
Publication year: 2018
Volume: 2018
ISSN: 2090-214X
eISSN: 2090-2158


Abstract

Cardiovascular complications are extremely frequent in patients with chronic kidney disease (CKD) and death from cardiac causes is the most common cause of death in this particular population. Cardiovascular disease is approximately 3 times more frequent in patients with CKD than in other known cardiovascular risk groups and cardiovascular mortality is approximately 10-fold more frequent in patients on dialysis compared to the age- and sex-matched segments of the nonrenal population. Among other structural and functional factors advanced calcification of atherosclerotic plaques as well as of the arterial and venous media has been described as potentially relevant for this high cardiovascular morbidity and mortality. One potential explanation for this exceedingly high vascular calcification in animal models as well as in patients with CKD increased systemic and most importantly local (micro)inflammation that has been shown to favor the development of calcifying particles by multiple ways. Of note, local vascular upregulation of proinflammatory and proosteogenic molecules is already present at early stages of CKD and may thus be operative for vascular calcification. In addition, increased expression of costimulatory molecules and mast cells has also been documented in patients with CKD pointing to a more inflammatory and potentially less stable phenotype of coronary atherosclerotic plaques in CKD.


FAU Authors / FAU Editors

Amann, Kerstin Ute Prof. Dr.
Nephropathologische Abteilung im Pathologischen Institut
Benz, Kerstin PD Dr.
Medizinische Fakultät
Daniel, Christoph Prof. Dr.
Nephropathologische Abteilung im Pathologischen Institut
Hilgers, Karl Friedrich Prof. Dr. med.
Professur für Innere Medizin (Hochdruckforschung)


How to cite

APA:
Benz, K., Hilgers, K.F., Daniel, C., & Amann, K.U. (2018). Vascular Calcification in Chronic Kidney Disease: The Role of Inflammation. International Journal of Nephrology, 2018. https://dx.doi.org/10.1155/2018/4310379

MLA:
Benz, Kerstin, et al. "Vascular Calcification in Chronic Kidney Disease: The Role of Inflammation." International Journal of Nephrology 2018 (2018).

BibTeX: 

Last updated on 2019-07-02 at 20:08