Genetic noise mechanism for power-law switching in bacterial flagellar motors

Journal article


Publication Details

Author(s): Krivonosov MI, Zaburdaev V, Denisov SV, Ivanchenko MV
Journal: Journal of Physics A: Mathematical and Theoretical
Publisher: IOP PUBLISHING LTD
Publication year: 2018
Volume: 51
Journal issue: 26
ISSN: 1751-8113
eISSN: 1751-8121


Abstract

Switching of the direction of flagella rotations is the key control mechanism governing the chemotactic activity of E. coli and many other bacteria. Power-law distributions of switching times are most peculiar because their emergence cannot be deduced from simple thermodynamic arguments. Recently, it was suggested that by adding finite-time correlations into Gaussian fluctuations regulating the energy height of the barrier between the two rotation states, it is possible to generate switching statistics with an intermediate power-law asymptotics. By using a simple model of a regulatory pathway, we demonstrate that the required amount of correlated 'noise' can be produced by finite number fluctuations of reacting protein molecules, a condition common to the intracellular chemistry. The corresponding power-law exponent appears as a tunable characteristic controlled by parameters of the regulatory pathway network such as the equilibrium number of molecules, sensitivities, and the characteristic relaxation time.


Additional Organisation
Lehrstuhl für Mathematik in den Lebenswissenschaften


External institutions with authors

Lobachevsky State University of Nizhni Novgorod


How to cite

APA:
Krivonosov, M.I., Zaburdaev, V., Denisov, S.V., & Ivanchenko, M.V. (2018). Genetic noise mechanism for power-law switching in bacterial flagellar motors. Journal of Physics A: Mathematical and Theoretical, 51(26). https://dx.doi.org/10.1088/1751-8121/aac543

MLA:
Krivonosov, M. I., et al. "Genetic noise mechanism for power-law switching in bacterial flagellar motors." Journal of Physics A: Mathematical and Theoretical 51.26 (2018).

BibTeX: 

Last updated on 2019-06-03 at 14:38