Genetic noise mechanism for power-law switching in bacterial flagellar motors
Krivonosov MI, Zaburdaev V, Denisov SV, Ivanchenko MV (2018)
Publication Status: Published
Publication Type: Journal article
Publication year: 2018
Journal
Publisher: IOP PUBLISHING LTD
Book Volume: 51
Journal Issue: 26
Abstract
Switching of the direction of flagella rotations is the key control mechanism governing the chemotactic activity of E. coli and many other bacteria. Power-law distributions of switching times are most peculiar because their emergence cannot be deduced from simple thermodynamic arguments. Recently, it was suggested that by adding finite-time correlations into Gaussian fluctuations regulating the energy height of the barrier between the two rotation states, it is possible to generate switching statistics with an intermediate power-law asymptotics. By using a simple model of a regulatory pathway, we demonstrate that the required amount of correlated 'noise' can be produced by finite number fluctuations of reacting protein molecules, a condition common to the intracellular chemistry. The corresponding power-law exponent appears as a tunable characteristic controlled by parameters of the regulatory pathway network such as the equilibrium number of molecules, sensitivities, and the characteristic relaxation time.
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Russian Federation (RU)How to cite
APA:
Krivonosov, M.I., Zaburdaev, V., Denisov, S.V., & Ivanchenko, M.V. (2018). Genetic noise mechanism for power-law switching in bacterial flagellar motors. Journal of Physics A: Mathematical and Theoretical, 51(26). https://dx.doi.org/10.1088/1751-8121/aac543
MLA:
Krivonosov, M. I., et al. "Genetic noise mechanism for power-law switching in bacterial flagellar motors." Journal of Physics A: Mathematical and Theoretical 51.26 (2018).
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