Quantitative assessment of microperfusion by indocyanine green angiography in kidney transplantation resembles chronic morphological changes in kidney specimens

Journal article


Publication Details

Author(s): Rother U, Amann KU, Adler W, Nawroth N, Karampinis I, Keese M, Manap S, Regus S, Meyer A, Porubsky S, Hilgers KF, Krämer BK, Lang W, Nowak K, Gerken AL
Journal: Microcirculation
Publication year: 2019
ISSN: 1073-9688


Abstract

OBJECTIVE: Indocyanine green fluorescence angiography enables a quantitative real-time perfusion assessment in kidney transplantation. The results of intraoperative microperfusion of the kidney allograft were compared to the renal chronicity score in pre-transplantation kidney biopsy specimens. The intrarenal resistance index was calculated by duplex sonography as a method of reference.
METHODS: Seventy-seven patients with end stage renal disease undergoing kidney transplantation were prospectively included in two centers. Correlation analysis of chronic changes in kidney biopsy specimens and the ingress of ICG fluorescence signal were investigated.
RESULTS: The results yielded a significantly negative correlation for the renal chronicity (r= -0.294, p=0.017) as well as the intestinal fibrosis and tubular atrophy score (r=-0.328, p=0.007). There was a significant inverse relationship between the ingress and the mean RI values of the upper pole of the kidney allograft.
CONCLUSION: In summary, fluorescence angiography reflects preexisting morphological changes of the renal cortex. ICG angiography may serve as an alternative method for the assessment of microperfusion of the kidney allograft. This article is protected by copyright. All rights reserved.


FAU Authors / FAU Editors

Adler, Werner PD Dr.
Lehrstuhl für Biometrie und Epidemiologie
Amann, Kerstin Ute Prof. Dr.
Nephropathologische Abteilung im Pathologischen Institut
Hilgers, Karl Friedrich Prof. Dr. med.
Professur für Innere Medizin (Hochdruckforschung)
Lang, Werner apl. Prof. Dr.
Gefäßchirurgische Abteilung
Regus, Susanne PD Dr.
Gefäßchirurgische Abteilung
Rother, Ulrich Dr. med.
Professur für Plastische Chirurgie und Handchirurgie


External institutions with authors

Universitätsklinikum Mannheim


How to cite

APA:
Rother, U., Amann, K.U., Adler, W., Nawroth, N., Karampinis, I., Keese, M.,... Gerken, A.L. (2019). Quantitative assessment of microperfusion by indocyanine green angiography in kidney transplantation resembles chronic morphological changes in kidney specimens. Microcirculation. https://dx.doi.org/10.1111/micc.12529

MLA:
Rother, Ulrich, et al. "Quantitative assessment of microperfusion by indocyanine green angiography in kidney transplantation resembles chronic morphological changes in kidney specimens." Microcirculation (2019).

BibTeX: 

Last updated on 2019-26-03 at 10:08