Quantitative assessment of microperfusion by indocyanine green angiography in kidney transplantation resembles chronic morphological changes in kidney specimens

Rother U, Amann KU, Adler W, Nawroth N, Karampinis I, Keese M, Manap S, Regus S, Meyer A, Porubsky S, Hilgers KF, Krämer BK, Lang W, Nowak K, Gerken AL (2019)


Publication Type: Journal article

Publication year: 2019

Journal

DOI: 10.1111/micc.12529

Abstract

OBJECTIVE: Indocyanine green fluorescence angiography enables a quantitative real-time perfusion assessment in kidney transplantation. The results of intraoperative microperfusion of the kidney allograft were compared to the renal chronicity score in pre-transplantation kidney biopsy specimens. The intrarenal resistance index was calculated by duplex sonography as a method of reference. METHODS: Seventy-seven patients with end stage renal disease undergoing kidney transplantation were prospectively included in two centers. Correlation analysis of chronic changes in kidney biopsy specimens and the ingress of ICG fluorescence signal were investigated. RESULTS: The results yielded a significantly negative correlation for the renal chronicity (r= -0.294, p=0.017) as well as the intestinal fibrosis and tubular atrophy score (r=-0.328, p=0.007). There was a significant inverse relationship between the ingress and the mean RI values of the upper pole of the kidney allograft. CONCLUSION: In summary, fluorescence angiography reflects preexisting morphological changes of the renal cortex. ICG angiography may serve as an alternative method for the assessment of microperfusion of the kidney allograft. This article is protected by copyright. All rights reserved.

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APA:

Rother, U., Amann, K.U., Adler, W., Nawroth, N., Karampinis, I., Keese, M.,... Gerken, A.L. (2019). Quantitative assessment of microperfusion by indocyanine green angiography in kidney transplantation resembles chronic morphological changes in kidney specimens. Microcirculation. https://dx.doi.org/10.1111/micc.12529

MLA:

Rother, Ulrich, et al. "Quantitative assessment of microperfusion by indocyanine green angiography in kidney transplantation resembles chronic morphological changes in kidney specimens." Microcirculation (2019).

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