Treadmill exercise intervention improves gait and postural control in alpha-synuclein mouse models without inducing cerebral autophagy

Journal article
(Original article)


Publication Details

Author(s): Minakaki G, Canneva F, Chevessier F, Bode F, Menges S, Timotius I, Kalinichenko L, Meixner H, Müller CP, Eskofier B, Casadei N, Riess O, Schröder R, Winkler J, Xiang W, von Hörsten S, Klucken J
Journal: Behavioural Brain Research
Publication year: 2019
Volume: 363
Pages range: 199-215
ISSN: 0166-4328
Language: English


Abstract

Gait and postural control dysfunction are prototypical symptoms compromising quality of life for patients with Parkinson’s disease (PD). Hallmarks of cellular pathology are dopaminergic degeneration and accumulation of the cytosolic protein alpha-synuclein, linked to impaired autophagy-lysosome pathway (ALP) clearance. Physical exercise improves gait in PD patients and motor function in rodent lesion models. Moreover, exercise is considered neuroprotective and ALP induction has been reported, e.g. in human skeletal muscle, rodent peripheral and cerebral tissues. A combined analysis of how distinct exercise paradigms affect motor and central biochemical aspects of PD could maximize benefits for patients. Here we examine the effect of 4 weeks treadmill exercise intervention in 7-8 month non-lesioned mice on a) distinct gait categories, b) ALP activity, c) dopaminergic and alpha-synuclein homeostasis. The study includes wild type, alpha-synuclein knockout, and mice exclusively expressing human alpha-synuclein. Parameters of gait regularity and stability, activity, and dynamic postural control during unforced walk, were assessed by an automated system (CatWalk XT). At baseline, alpha-synuclein mouse models exhibited irregular and less active gait, with impaired dynamic postural control, compared to wild type mice. Treadmill exercise particularly improved speed and stride length, while increasing dual diagonal versus three-paw body support in both the alpha-synuclein knockout and transgenic mice. Biochemical analyses showed higher striatal tyrosine hydroxylase immuno-reactivity and reduced higher-order alpha-synuclein species in the cerebral cortex. However, no significant cerebral ALP induction was measured. In summary, treadmill exercise improved gait activity and postural stability, and promoted dopaminergic and alpha-synuclein homeostasis, without robustly inducing cerebral ALP.


FAU Authors / FAU Editors

Eskofier, Björn Prof. Dr.
Lehrstuhl für Informatik 14 (Maschinelles Lernen und Datenanalytik)
Kalinichenko, Liubov
Professur für Suchtmedizin
Klucken, Jochen Prof. Dr.
Molekular-Neurologische Abteilung in der Neurologischen Klinik
Menges, Stefanie
Professur für Molekulare Neurologie
Minakaki, Georgia
Professur für Molekulare Neurologie
Müller, Christian P. Prof. Dr.
Professur für Suchtmedizin
Schröder, Rolf Prof. Dr.
Professur für Neuropathologie
Timotius, Ivanna
Lehrstuhl für Informatik 5 (Mustererkennung)
von Hörsten, Stephan Prof. Dr.
Professur für Experimentelle Biomedizin
Winkler, Jürgen Prof. Dr.
Molekular-Neurologische Abteilung in der Neurologischen Klinik
Xiang, Wei PD Dr.
Lehrstuhl für Biochemie und Molekulare Medizin


External institutions
Eberhard Karls Universität Tübingen


How to cite

APA:
Minakaki, G., Canneva, F., Chevessier, F., Bode, F., Menges, S., Timotius, I.,... Klucken, J. (2019). Treadmill exercise intervention improves gait and postural control in alpha-synuclein mouse models without inducing cerebral autophagy. Behavioural Brain Research, 363, 199-215. https://dx.doi.org/10.1016/j.bbr.2018.11.035

MLA:
Minakaki, Georgia, et al. "Treadmill exercise intervention improves gait and postural control in alpha-synuclein mouse models without inducing cerebral autophagy." Behavioural Brain Research 363 (2019): 199-215.

BibTeX: 

Last updated on 2019-14-02 at 10:38