ESC Working Group on Cellular Biology of the Heart: Tissue Engineering and Cell-Based Therapies for Cardiac Repair in Ischemic Heart Disease and Heart Failure

Madonna R, Van Laake LW, Botker HE, Davidson SM, De Caterina R, Engel F, Eschenhagen T, Fernandez-Aviles F, Hausenloy DJ, Hulot JS, Lecour S, Leor J, Menasché P, Pesce M, Perrino C, Prunier F, Van Linthout S, Ytrehus K, Zimmermann WH, Ferdinandy P, Sluijter JP (2019)

Publication Type: Journal article

Publication year: 2019

Journal

DOI: 10.1093/cvr/cvz010

Abstract

Morbidity and mortality from ischemic heart disease (IHD) and heart failure (HF) remain significant in Europe and are increasing worldwide. Patients with IHD or HF might benefit from novel therapeutic strategies, such as cell-based therapies. We recently discussed the therapeutic potential of cell-based therapies and provided recommendations on how to improve the therapeutic translation of these novel strategies for effective cardiac regeneration and repair. Despite major advances in optimizing these strategies with respect to cell source and delivery method, the clinical outcome of cell-based therapy remains unsatisfactory. Major obstacles are the low engraftment and survival rate of transplanted cells in the harmful microenvironment of the host tissue, and the paucity or even lack of endogenous cells with repair capacity. Therefore, new ways of delivering cells and their derivatives are required in order to empower cell-based cardiac repair and regeneration in patients with IHD or HF. Strategies using tissue engineering (TE) combine cells with matrix materials to enhance cell retention or cell delivery in the transplanted area, and have recently received much attention for this purpose. Here, we summarize knowledge on novel approaches emerging from the TE scenario. In particular, we will discuss how combinations of cell/bio-materials (e.g., hydrogels, cell sheets, prefabricated matrices, microspheres, and injectable matrices) combinations might enhance cell retention or cell delivery in the transplantation areas and thereby increase the success rate of cell therapies for IHD and HF. We will not focus on the use of classical engineering approaches, employing fully synthetic materials, because of their unsatisfactory material properties which render them not clinically applicable. The overall aim of this Position Paper from the ESC Working Group Cellular Biology of the Heart is to provide recommendations on how to proceed in research with these novel tissue engineering strategies combined with cell-based therapies to boost cardiac repair in the clinical settings of IHD and HF.

Authors with CRIS profile

Involved external institutions

Centro Cardiologico Monzino (IRCCS) Italy (IT) Georges Pompidou European Hospital / Hôpital Européen Georges-Pompidou (HEGP) France (FR) Chaim Sheba Medical Center at Tel HaShomer / המרכז הרפואי עש חיים שיבא – תל השומר‎‎ Israel (IL) University of Cape Town (UCT) South Africa (ZA) University Medical Centre Utrecht (UMC Utrecht) Netherlands (NL) Pharmahungary Group Hungary (HU) Universitätsklinikum Göttingen Germany (DE) Universitetet i Tromsø / The Arctic University of Norway (UiT) Norway (NO) Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK e.V.) Germany (DE) Université d'Angers France (FR) Università degli Studi di Napoli Federico II Italy (IT) Tecnológico de Monterrey (ITESM) Mexico (MX) IiSGM / Instituto de Investigación Sanitaria Gregorio Marañón Spain (ES) Universitätsklinikum Hamburg-Eppendorf (UKE) Germany (DE) Università degli Studi Gabriele D'Annunzio Italy (IT) Aarhus University Hospital / Aarhus Universitetshospital Denmark (DK)

How to cite

APA:

Madonna, R., Van Laake, L.W., Botker, H.E., Davidson, S.M., De Caterina, R., Engel, F.,... Sluijter, J.P. (2019). ESC Working Group on Cellular Biology of the Heart: Tissue Engineering and Cell-Based Therapies for Cardiac Repair in Ischemic Heart Disease and Heart Failure. Cardiovascular Research. https://doi.org/10.1093/cvr/cvz010

MLA:

Madonna, Rosalinda, et al. "ESC Working Group on Cellular Biology of the Heart: Tissue Engineering and Cell-Based Therapies for Cardiac Repair in Ischemic Heart Disease and Heart Failure." Cardiovascular Research (2019).

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