From design to the clinic: practical guidelines for translating cardiovascular nanomedicine

Beitrag in einer Fachzeitschrift

Details zur Publikation

Autorinnen und Autoren: Cicha I, Chauvierre C, Texier I, Cabella C, Metselaar JM, Szebeni J, Dezsi L, Alexiou C, Rouzet F, Storm G, Stroes E, Bruce D, Macritchie N, Maffia P, Letourneur D
Zeitschrift: Cardiovascular Research
Jahr der Veröffentlichung: 2018
Band: 114
Heftnummer: 13
Seitenbereich: 1714-1727
ISSN: 0008-6363


Cardiovascular diseases (CVD) account for nearly half of all deaths in Europe and almost 30% of global deaths. Despite the improved clinical management, cardiovascular mortality is predicted to rise in the next decades due to the increasing impact of aging, obesity, and diabetes. The goal of emerging cardiovascular nanomedicine is to reduce the burden of CVD using nanoscale medical products and devices. However, the development of novel multicomponent nano-sized products poses multiple technical, ethical, and regulatory challenges, which often obstruct their road to successful approval and use in clinical practice. This review discusses the rational design of nanoparticles, including safety considerations and regulatory issues, and highlights the steps needed to achieve efficient clinical translation of promising nanomedicinal products for cardiovascular applications.

FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Alexiou, Christoph Prof. Dr.
Professur für Nanomedizin
Cicha, Iwona Prof. Dr.
Medizinische Fakultät

Einrichtungen weiterer Autorinnen und Autoren

Academic Medical Centre / Academisch Medisch Centrum (AMC)
Bracco Imaging Italia srl
Edinethics Ltd.
Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen
Semmelweis University
Universiteit Utrecht (UU) / Utrecht University
University of Glasgow
University of Grenoble Alpes (UGA) / Université de Grenoble
University of Paris 13 - Paris-Nord / Université Paris XIII Paris-Nord


Cicha, I., Chauvierre, C., Texier, I., Cabella, C., Metselaar, J.M., Szebeni, J.,... Letourneur, D. (2018). From design to the clinic: practical guidelines for translating cardiovascular nanomedicine. Cardiovascular Research, 114(13), 1714-1727.

Cicha, Iwona, et al. "From design to the clinic: practical guidelines for translating cardiovascular nanomedicine." Cardiovascular Research 114.13 (2018): 1714-1727.


Zuletzt aktualisiert 2019-07-02 um 09:23