Drug delivery to atherosclerotic plaques using superparamagnetic iron oxide nanoparticles

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Matuszak J, Lutz B, Sekita A, Zaloga J, Alexiou C, Lyer S, Cicha I
Zeitschrift: International Journal of Nanomedicine
Jahr der Veröffentlichung: 2018
Band: 13
Seitenbereich: 8443-8460
ISSN: 1176-9114
eISSN: 1178-2013


Abstract

Introduction: Magnetic drug targeting utilizes superparamagnetic iron oxide nanoparticles (SPIONs) to accumulate drugs in specified vasculature regions.
Methods: We produced SPIONs conjugated with dexamethasone phosphate (SPION-DEXA). The efficacy of magnetic drug targeting was investigated in a rabbit model of atherosclerosis induced by balloon injury and high cholesterol diet.
Results: In vitro, SPION-DEXA were well-tolerated by endothelial cells. SPION-DEXA were internalized by human peripheral blood mononuclear cells and induced CD163 expression comparable with the free drug. In vivo, magnetic targeting of SPIONs to abdominal aorta was confirmed by histology. Upon vascular injury followed by high-cholesterol diet, early administration of SPION-DEXA enhanced the inflammatory burden in the plaques. Increased macrophage content and larger intima- media thickness were observed in animals treated with SPION-DEXA compared with controls. In advanced atherosclerosis, no beneficial effect of local glucocorticoid therapy was detectable.
Conclusion: Magnetic drug targeting represents an efficient platform to deliver drugs to diseased arteries in vivo. However, targeting of vascular injury in the lipid-rich environment using dexamethasone-conjugated SPIONs may cause accelerated inflammatory response.


FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Alexiou, Christoph Prof. Dr.
Professur für Nanomedizin
Cicha, Iwona Prof. Dr.
Medizinische Fakultät
Lutz, Barbara
Professur für Nanomedizin
Lyer, Stefan Dr. rer. nat.
Hals-Nasen-Ohren-Klinik - Kopf- und Halschirurgie
Matuszak, Jasmin
Hals-Nasen-Ohren-Klinik - Kopf- und Halschirurgie
Zaloga, Jan Dr. rer. nat.
Hals-Nasen-Ohren-Klinik - Kopf- und Halschirurgie


Zitierweisen

APA:
Matuszak, J., Lutz, B., Sekita, A., Zaloga, J., Alexiou, C., Lyer, S., & Cicha, I. (2018). Drug delivery to atherosclerotic plaques using superparamagnetic iron oxide nanoparticles. International Journal of Nanomedicine, 13, 8443-8460. https://dx.doi.org/10.2147/IJN.S179273

MLA:
Matuszak, Jasmin, et al. "Drug delivery to atherosclerotic plaques using superparamagnetic iron oxide nanoparticles." International Journal of Nanomedicine 13 (2018): 8443-8460.

BibTeX: 

Zuletzt aktualisiert 2019-04-02 um 16:38

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