Centrosomal protein TRIM43 restricts herpesvirus infection by regulating nuclear lamina integrity

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Full F, Van Gent M, Sparrer KMJ, Chiang C, Zurenski MA, Scherer M, Brockmeyer NH, Heinzerling L, Stürzl M, Korn K, Stamminger T, Enßer A, Gack MU
Zeitschrift: Nature Microbiology
Jahr der Veröffentlichung: 2019
Band: 4
Heftnummer: 1
Seitenbereich: 164-+
ISSN: 2058-5276


Abstract

Tripartite motif (TRIM) proteins mediate antiviral host defences by either directly targeting viral components or modulating innate immune responses. Here we identify a mechanism of antiviral restriction in which a TRIM E3 ligase controls viral replication by regulating the structure of host cell centrosomes and thereby nuclear lamina integrity. Through RNAi screening we identified several TRIM proteins, including TRIM43, that control the reactivation of Kaposi's sarcoma-associated herpesvirus. TRIM43 was distinguished by its ability to restrict a broad range of herpesviruses and its profound upregulation during herpesvirus infection as part of a germline-specific transcriptional program mediated by the transcription factor DUX4. TRIM43 ubiquitinates the centrosomal protein pericentrin, thereby targeting it for proteasomal degradation, which subsequently leads to alterations of the nuclear lamina that repress active viral chromatin states. Our study identifies a role of the TRIM43-pericentrin-lamin axis in intrinsic immunity, which may be targeted for therapeutic intervention against herpesviral infections.


FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Enßer, Armin Prof. Dr.
Medizinische Fakultät
Heinzerling, Lucie Prof. Dr.
Hautklinik
Stürzl, Michael Prof. Dr.
Professur für Molekulare und Experimentelle Chirurgie


Einrichtungen weiterer Autorinnen und Autoren

Ruhr-Universität Bochum (RUB)
Universität Ulm
University of Chicago


Zitierweisen

APA:
Full, F., Van Gent, M., Sparrer, K.M.J., Chiang, C., Zurenski, M.A., Scherer, M.,... Gack, M.U. (2019). Centrosomal protein TRIM43 restricts herpesvirus infection by regulating nuclear lamina integrity. Nature Microbiology, 4(1), 164-+. https://dx.doi.org/10.1038/s41564-018-0285-5

MLA:
Full, Florian, et al. "Centrosomal protein TRIM43 restricts herpesvirus infection by regulating nuclear lamina integrity." Nature Microbiology 4.1 (2019): 164-+.

BibTeX: 

Zuletzt aktualisiert 2019-04-02 um 08:23