Access to new highly potent antileukemia, antiviral and antimalarial agents via hybridization of natural products (homo)egonol, thymoquinone and artemisinin

Journal article


Publication Details

Author(s): Capci Karagoez A, Reiter C, Seo EJ, Gruber L, Hahn F, Leidenberger M, Klein V, Hampel F, Friedrich O, Marschall M, Kappes B, Efferth T, Tsogoeva S
Journal: Bioorganic & Medicinal Chemistry
Publication year: 2018
Volume: 26
Journal issue: 12
Pages range: 3610-3618
ISSN: 0968-0896


Abstract

Hybridization of natural products has high potential to further improve their activities and may produce synergistic effects between linked pharmacophores. Here we report synthesis of nine new hybrids of natural products egonol, homoegonol, thymoquinone and artemisinin and evaluation of their activities against P. falciparum 3D7 parasites, human cytomegalovirus, sensitive and multidrug-resistant human leukemia cells. Most of the new hybrids exceed their parent compounds in antimalarial, antiviral and antileukemia activities and in some cases show higher in vitro efficacy than clinically used reference drugs chloroquine, ganciclovir and doxorubicin. Combined, our findings stress the high potency of these hybrids and encourages further use of the hybridization concept in applied pharmacological research.


FAU Authors / FAU Editors

Capci Karagoez, Aysun
Professur für Organische Chemie
Friedrich, Oliver Prof. Dr. Dr.
Lehrstuhl für Medizinische Biotechnologie
Hahn, Friedrich
Professur für Virologie
Hampel, Frank Dr.
Lehrstuhl für Organische Chemie I
Kappes, Bärbel Prof. Dr.
Lehrstuhl für Medizinische Biotechnologie
Klein, Volker
Lehrstuhl für Organische Chemie I
Leidenberger, Maria
Lehrstuhl für Medizinische Biotechnologie
Tsogoeva, Svetlana Prof. Dr.
Professur für Organische Chemie


External institutions with authors

Johannes Gutenberg-Universität Mainz


How to cite

APA:
Capci Karagoez, A., Reiter, C., Seo, E.-J., Gruber, L., Hahn, F., Leidenberger, M.,... Tsogoeva, S. (2018). Access to new highly potent antileukemia, antiviral and antimalarial agents via hybridization of natural products (homo)egonol, thymoquinone and artemisinin. Bioorganic & Medicinal Chemistry, 26(12), 3610-3618. https://dx.doi.org/10.1016/j.bmc.2018.05.041

MLA:
Capci Karagoez, Aysun, et al. "Access to new highly potent antileukemia, antiviral and antimalarial agents via hybridization of natural products (homo)egonol, thymoquinone and artemisinin." Bioorganic & Medicinal Chemistry 26.12 (2018): 3610-3618.

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Last updated on 2019-21-07 at 07:29