Serum organochlorines and non-Hodgkin lymphoma: A case-control study in Israeli Jews and Palestinians

Beitrag in einer Fachzeitschrift

Details zur Publikation

Autorinnen und Autoren: Klil-Drori AJ, Kleinstern G, Abu Seir R, Choshen-Cohen L, Abdeen Z, Hussein E, Aqel M, Göen T, Perlman R, Ben-Yehuda D, Paltiel O
Zeitschrift: Chemosphere
Jahr der Veröffentlichung: 2018
Band: 213
Seitenbereich: 395-402
ISSN: 0045-6535


Associations of organochlorine (OC) pesticides and polychlorinated biphenyls (PCBs) with non-Hodgkin lymphoma are controversial. We compared serum levels of 6 OC pesticides and 38 PCBs in Israeli Jews (IJ) and Palestinian Arabs (PA) and assessed possible associations with B-cell non-Hodgkin lymphoma (B-NHL). Ninety B-NHL cases (50 IJ and 40 PA) and 120 controls (65 IJ and 55 PA) were included. Median concentrations of analytes in controls were compared across ethnic groups using quantile regression, adjusting for age and sex. We used logistic regression to derive odds ratios (OR) and 95% confidence intervals (CI) for detectable analytes and B-NHL, adjusting for age, ethnic group, faming and body mass index. Median values of PCBs and dichlorodiphenyldichloroethylene (DDE) were higher in IJ vs PA controls (P = 0.0007), as were several PCBs (74, 99, 118, 138, 146, 153, 156, 163, 170, and 180). Overall, OC pesticide and PCB exposures were comparable with reports from high-income countries. B-NHL was associated with PCB 146 (OR 1.70, 95% CI: 1.02, 2.83), PCB 156 (OR 1.75, 95% CI: 1.06, 2.89), and high-chlorinated PCBs (OR 1.55, 95% CI: 1.00, 2.40) in all study subjects. These associations were robust in quantile as well as sensitivity analyses. An association of DDE with B-NHL was noted in PA (OR 1.72, 95% CI: 1.07, 2.77), but not in IJ (OR 0.87, 95% CI: 0.59, 1.27). Although high-chlorinated PCB concentrations did not indicate high exposure levels, our findings indicate that B-NHL may be associated with this exposure.

FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Göen, Thomas Prof. Dr.
Lehrstuhl für Arbeits- und Sozialmedizin

Einrichtungen weiterer Autorinnen und Autoren

Al-Quds University / جامعة القدس‎‎
Augusta Victoria Hospital / מתחם אוגוסטה ויקטוריה
Beit Jala Hospital
Hadassah Medical Center / מרכז רפואי הדסה‎‎
Hôpital général juif - Jewish General Hospital


Klil-Drori, A.J., Kleinstern, G., Abu Seir, R., Choshen-Cohen, L., Abdeen, Z., Hussein, E.,... Paltiel, O. (2018). Serum organochlorines and non-Hodgkin lymphoma: A case-control study in Israeli Jews and Palestinians. Chemosphere, 213, 395-402.

Klil-Drori, Adi J., et al. "Serum organochlorines and non-Hodgkin lymphoma: A case-control study in Israeli Jews and Palestinians." Chemosphere 213 (2018): 395-402.


Zuletzt aktualisiert 2019-01-02 um 08:38