Highly dispersed lithium doped mesoporous silica nanospheres regulating adhesion, proliferation, morphology, ALP activity and osteogenesis related gene expressions of BMSCs.

Journal article


Publication Details

Author(s): Zhang J, Cai L, Tang L, Zhang X, Yang L, Zheng K, He A, Boccaccini AR, Wei J, Zhao J
Journal: Colloids and Surfaces B-Biointerfaces
Publication year: 2018
Volume: 170
Pages range: 563-571
ISSN: 0927-7765


Abstract

Lithium (Li) doped mesoporous silica nanospheres (LMSNs) were synthesized by incorporation of 5 wt% Li into mesoporous silica nanospheres (MSNs) using sol-gel method. The results showed that LMSNs with a mean size of approximate 300 nm exhibited uniform and highly dispersed spherical morphology, which was similar to the morphology of MSNs. Moreover, the degradability of MSNs was significantly increased after the incorporation of Li, and LMSNs could release both silicon (Si) and Li ions in a sustained manner. Due to the release of Li ions, LMSNs showed higher stimulatory effects on the attachment and proliferation of bone marrow mesenchymal stem cells (BMSCs) than MSNs. In addition, LMSNs could also enhance the ALP activity of BMSCs as well as improving osteogenesis related genes (OPN, ALP, Runx2 and OCN) expression of BMSCs. In summary, LMSNs have shown the capability of being a carrier of biologically active ions, which exhibit great potential in bone repair/regeneration applications.


FAU Authors / FAU Editors

Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Zheng, Kai Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)


External institutions with authors

East China University of Science and Technology (ECUST)
Second Military Medical University (SMMU) / 第二军医大学
Shanghai Jiao Tong University / 上海交通大学


How to cite

APA:
Zhang, J., Cai, L., Tang, L., Zhang, X., Yang, L., Zheng, K.,... Zhao, J. (2018). Highly dispersed lithium doped mesoporous silica nanospheres regulating adhesion, proliferation, morphology, ALP activity and osteogenesis related gene expressions of BMSCs. Colloids and Surfaces B-Biointerfaces, 170, 563-571. https://dx.doi.org/10.1016/j.colsurfb.2018.06.038

MLA:
Zhang, Jue, et al. "Highly dispersed lithium doped mesoporous silica nanospheres regulating adhesion, proliferation, morphology, ALP activity and osteogenesis related gene expressions of BMSCs." Colloids and Surfaces B-Biointerfaces 170 (2018): 563-571.

BibTeX: 

Last updated on 2019-18-07 at 07:17