Highly dispersed lithium doped mesoporous silica nanospheres regulating adhesion, proliferation, morphology, ALP activity and osteogenesis related gene expressions of BMSCs.

Zhang J, Cai L, Tang L, Zhang X, Yang L, Zheng K, He A, Boccaccini AR, Wei J, Zhao J (2018)

Publication Status: Published

Publication Type: Journal article

Publication year: 2018

Journal

Colloids and Surfaces B-Biointerfaces Elsevier

Book Volume: 170

Pages Range: 563-571

DOI: 10.1016/j.colsurfb.2018.06.038

Abstract

Lithium (Li) doped mesoporous silica nanospheres (LMSNs) were synthesized by incorporation of 5 wt% Li into mesoporous silica nanospheres (MSNs) using sol-gel method. The results showed that LMSNs with a mean size of approximate 300 nm exhibited uniform and highly dispersed spherical morphology, which was similar to the morphology of MSNs. Moreover, the degradability of MSNs was significantly increased after the incorporation of Li, and LMSNs could release both silicon (Si) and Li ions in a sustained manner. Due to the release of Li ions, LMSNs showed higher stimulatory effects on the attachment and proliferation of bone marrow mesenchymal stem cells (BMSCs) than MSNs. In addition, LMSNs could also enhance the ALP activity of BMSCs as well as improving osteogenesis related genes (OPN, ALP, Runx2 and OCN) expression of BMSCs. In summary, LMSNs have shown the capability of being a carrier of biologically active ions, which exhibit great potential in bone repair/regeneration applications.

Authors with CRIS profile

Kai Zheng Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Shanghai Jiao Tong University / 上海交通大学 CN China (CN) East China University of Science and Technology (ECUST) CN China (CN) Second Military Medical University (SMMU) / 第二军医大学 CN China (CN)

How to cite

APA:

Zhang, J., Cai, L., Tang, L., Zhang, X., Yang, L., Zheng, K.,... Zhao, J. (2018). Highly dispersed lithium doped mesoporous silica nanospheres regulating adhesion, proliferation, morphology, ALP activity and osteogenesis related gene expressions of BMSCs. Colloids and Surfaces B-Biointerfaces, 170, 563-571. https://dx.doi.org/10.1016/j.colsurfb.2018.06.038

MLA:

Zhang, Jue, et al. "Highly dispersed lithium doped mesoporous silica nanospheres regulating adhesion, proliferation, morphology, ALP activity and osteogenesis related gene expressions of BMSCs." Colloids and Surfaces B-Biointerfaces 170 (2018): 563-571.

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