Encapsulation of Mesenchymal Stem Cells Improves Vascularization of Alginate-Based Scaffolds.

Journal article


Publication Details

Author(s): Steiner D, Lingens L, Fischer L, Köhn K, Detsch R, Boccaccini AR, Fey T, Greil P, Weis C, Beier J, Horch RE, Arkudas A
Journal: Tissue Engineering: Parts A, B, and C
Publication year: 2018
Volume: 24
Journal issue: 17-18
Pages range: 1320-1331
ISSN: 1937-3368
eISSN: 1557-8690


Abstract

DiI-labeled MSCs/mL ADA-GEL. Four weeks postoperatively, tissue formation and vascularization were investigated by histology and microcomputed tomography. We were able to prove vascularization originating from the AV loop in both groups with statistically significant more vessels in group B containing MSCs. Moreover, encapsulated MSCs promoted biodegradation of the ADA-GEL microcapsules. In the present study, we were able to demonstrate for the first time, the successful vascularization of ADA-GEL microcapsules by means of the AV loop. Furthermore, ADA-GEL displayed a good biocompatibility and encapsulation of MSCs into ADA-GEL microcapsule-enhanced vascularization as well as biodegradation.


FAU Authors / FAU Editors

Arkudas, Andreas Prof. Dr.
Medizinische Fakultät
Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Detsch, Rainer Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Fey, Tobias Dr.
Lehrstuhl für Werkstoffwissenschaften (Glas und Keramik)
Fischer, Laura
Plastisch- und Handchirurgische Klinik
Greil, Peter Prof. Dr.
Lehrstuhl für Werkstoffwissenschaften (Glas und Keramik)
Horch, Raymund E. Prof. Dr.
Professur für Plastische Chirurgie und Handchirurgie
Köhn, Katrin
Plastisch- und Handchirurgische Klinik
Lingens, Lara
Plastisch- und Handchirurgische Klinik
Steiner, Dominik Dr. med.
Plastisch- und Handchirurgische Klinik


How to cite

APA:
Steiner, D., Lingens, L., Fischer, L., Köhn, K., Detsch, R., Boccaccini, A.R.,... Arkudas, A. (2018). Encapsulation of Mesenchymal Stem Cells Improves Vascularization of Alginate-Based Scaffolds. Tissue Engineering: Parts A, B, and C, 24(17-18), 1320-1331. https://dx.doi.org/10.1089/ten.TEA.2017.0496

MLA:
Steiner, Dominik, et al. "Encapsulation of Mesenchymal Stem Cells Improves Vascularization of Alginate-Based Scaffolds." Tissue Engineering: Parts A, B, and C 24.17-18 (2018): 1320-1331.

BibTeX: 

Last updated on 2019-23-05 at 09:23