Polylactide-based materials science strategies to improve tissue-material interface without the use of growth factors or other biological molecules.

Gritsch L, Conoscenti G, La Carrubba V, Nooeaid P, Boccaccini AR (2019)

Publication Status: Published

Publication Type: Journal article, Review article

Publication year: 2019

Journal

Materials Science and Engineering C Elsevier

Book Volume: 94

Pages Range: 1083-1101

DOI: 10.1016/j.msec.2018.09.038

Abstract

In a large number of medical devices, a key feature of a biomaterial is the ability to successfully bond to living tissues by means of engineered mechanisms such as the enhancement of biomineralization on a bone tissue engineering scaffold or the mimicking of the natural structure of the extracellular matrix (ECM). This ability is commonly referred to as "bioactivity". Materials sciences started to grow interest in it since the development of bioactive glasses by Larry Hench five decades ago. As the main goal in applications of biomedical devices and tissue scaffolds is to obtain a seamless tissue-material interface, achieving optimal bioactivity is essential for the success of most biomaterial-based tissue replacement and regenerative approaches. Polymers derived from lactic acid are largely adopted in the biomedical field, they are versatile, FDA approved and relatively cost-effective. However, as for many other widespread biomedical polymers, they are hydrophobic and lack the intrinsic ability of positively interacting with surrounding tissues. In the last decades scientists have studied many solutions to exploit the positive characteristics of polylactide-based materials overcoming this bottleneck at the same time. The efforts of this research fruitfully produced many effective tissue engineering technologies based on PLA and related biopolymers. This review aims to give an overview on the latest and most promising strategies to improve the bioactivity of lactic acid-based materials, especially focusing on biomolecule-free bulk approaches such as blending, copolymerization or composite fabrication. Avenues for future research to tackle current needs in the field are identified and discussed.

Authors with CRIS profile

Lukas Gritsch Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Srinakharinwirot University / มหาวิทยาลัยศรีนครินทรวิโรฒ TH Thailand (TH) Università degli Studi di Palermo IT Italy (IT)

How to cite

APA:

Gritsch, L., Conoscenti, G., La Carrubba, V., Nooeaid, P., & Boccaccini, A.R. (2019). Polylactide-based materials science strategies to improve tissue-material interface without the use of growth factors or other biological molecules. Materials Science and Engineering C, 94, 1083-1101. https://dx.doi.org/10.1016/j.msec.2018.09.038

MLA:

Gritsch, Lukas, et al. "Polylactide-based materials science strategies to improve tissue-material interface without the use of growth factors or other biological molecules." Materials Science and Engineering C 94 (2019): 1083-1101.

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