Electrospun Polyhydroxybutyrate/Poly(ε-caprolactone)/Sol-Gel-Derived Silica Hybrid Scaffolds with Drug Releasing Function for Bone Tissue Engineering Applications.

Journal article


Publication Details

Author(s): Ding Y, Li W, Correia A, Yang Y, Zheng K, Liu D, Schubert DW, Boccaccini AR, Santos HA, Roether J
Journal: ACS Applied Materials and Interfaces
Publication year: 2018
Volume: 10
Journal issue: 17
Pages range: 14540-14548
ISSN: 1944-8244


Abstract

Electrospun hybrid scaffolds are an effective platform to deliver drugs site specifically for the prevention and treatment of diseases in addition to promote tissue regeneration because of the flexibility to load drugs therein. In the present study, electrospun hybrid scaffolds containing antibiotics were developed to support cellular activities and eliminate potential postoperative inflammation and infection. As a model drug, levofloxacin (LFX) was successfully incorporated into pure polyhydroxybutyrate/poly(ε-caprolactone) (PHB/PCL) scaffolds and PHB/PCL/sol-gel-derived silica (SGS) scaffolds. The influence of LFX on the morphology, mechanical performance, chemical structure, drug release profile, and antibacterial effect of the scaffolds was thoroughly and comparatively investigated. MG-63 osteoblast-like cell cultivation on both scaffolds certified that LFX inclusion did not impair the biocompatibility. In addition to the favorable cellular proliferation and differentiation, scaffolds containing both LFX and SGS displayed highly increased mineralization content. Therefore, the present multifunctional hybrid scaffolds are promising in tissue engineering applications.


FAU Authors / FAU Editors

Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Roether, Judith
Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe)
Schubert, Dirk W. Prof. Dr.
Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe)
Yang, Yuyun
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Zheng, Kai Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)


External institutions with authors

Helsingin yliopisto / University of Helsinki


How to cite

APA:
Ding, Y., Li, W., Correia, A., Yang, Y., Zheng, K., Liu, D.,... Roether, J. (2018). Electrospun Polyhydroxybutyrate/Poly(ε-caprolactone)/Sol-Gel-Derived Silica Hybrid Scaffolds with Drug Releasing Function for Bone Tissue Engineering Applications. ACS Applied Materials and Interfaces, 10(17), 14540-14548. https://dx.doi.org/10.1021/acsami.8b02656

MLA:
Ding, Yaping, et al. "Electrospun Polyhydroxybutyrate/Poly(ε-caprolactone)/Sol-Gel-Derived Silica Hybrid Scaffolds with Drug Releasing Function for Bone Tissue Engineering Applications." ACS Applied Materials and Interfaces 10.17 (2018): 14540-14548.

BibTeX: 

Last updated on 2019-20-03 at 11:38