Histamine intolerance: Causes, diagnosis and therapy

Schink M, Tietz E, Zopf Y (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Allergologie Dustri-Verlag

Book Volume: 41

Pages Range: 314-320

Journal Issue: 7

Abstract

At present, histamine intolerance (HIT) represents a controversial condition. An impaired degradation of orally supplied histamine due to diamine oxidase (DAO) deficiency is assumed to be the leading cause. Histamine-rich or -liberating foods as well as DAO-inhibiting drugs are discussed as exogenous sources. Endogenously, histamine is produced by mast cells, basophils, or enterochromaffin cells. Because of a broad range of gastrointestinal (diarrhea, nausea, vomiting) and extra-intestinal symptoms (headache, flush, rash) as well as an unclear diagnostic approach, diagnosis is difficult at present. The exclusion of other differential diagnoses, including carbohydrate malabsorption or mastocytosis, plays an important role. Therapeutically, a histamine-reduced diet seems to be the first choice, adjusted to the individual tolerance threshold and supported by a professional dietician.

Authors with CRIS profile

Monic Schink Professur für Integrative Medizin mit dem Schwerpunkt Ernährungsmedizin (Stiftungsprofessur der Hector Stiftung II gGmbH) Yurdagül Zopf Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology

How to cite

APA:

Schink, M., Tietz, E., & Zopf, Y. (2018). Histamine intolerance: Causes, diagnosis and therapy. Allergologie, 41(7), 314-320.

MLA:

Schink, Monic, E. Tietz, and Yurdagül Zopf. "Histamine intolerance: Causes, diagnosis and therapy." Allergologie 41.7 (2018): 314-320.

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