Regulation of Energy Metabolism during Early B Lymphocyte Development

Urbanczyk S, Stein M, Schuh W, Jäck HM, Mougiakakos D, Mielenz D (2018)

Publication Type: Journal article

Publication year: 2018

Journal

International Journal of Molecular Sciences MDPI

Book Volume: 19

Journal Issue: 8

DOI: 10.3390/ijms19082192

Abstract

The most important feature of humoral immunity is the adaptation of the diversity of newly generated B cell receptors, that is, the antigen receptor repertoire, to the body's own and foreign structures. This includes the transient propagation of B progenitor cells and B cells, which possess receptors that are positively selected via anabolic signalling pathways under highly competitive conditions. The metabolic regulation of early B-cell development thus has important consequences for the expansion of normal or malignant pre-B cell clones. In addition, cellular senescence programs based on the expression of B cell identity factors, such as Pax5, act to prevent excessive proliferation and cellular deviation. Here, we review the basic mechanisms underlying the regulation of glycolysis and oxidative phosphorylation during early B cell development in bone marrow. We focus on the regulation of glycolysis and mitochondrial oxidative phosphorylation at the transition from non-transformed pro- to pre-B cells and discuss some ongoing issues. We introduce Swiprosin-2/EFhd1 as a potential regulator of glycolysis in pro-B cells that has also been linked to Ca2+-mediated mitoflashes. Mitoflashes are bioenergetic mitochondrial events that control mitochondrial metabolism and signalling in both healthy and disease states. We discuss how Ca2+ fluctuations in pro- and pre-B cells may translate into mitoflashes in early B cells and speculate about the consequences of these changes.

Authors with CRIS profile

Sophia Urbanczyk Department of Molecular Immunology Wolfgang Schuh Department of Molecular Immunology Hans-Martin Jäck Department of Molecular Immunology Dimitrios Mougiakakos Professur für Hämatologie/Onkologie mit dem Schwerpunkt Tumorimmunologie Dirk Mielenz Medizinische Fakultät

Involved external institutions

Universität Ulm DE Germany (DE)

How to cite

APA:

Urbanczyk, S., Stein, M., Schuh, W., Jäck, H.-M., Mougiakakos, D., & Mielenz, D. (2018). Regulation of Energy Metabolism during Early B Lymphocyte Development. International Journal of Molecular Sciences, 19(8). https://doi.org/10.3390/ijms19082192

MLA:

Urbanczyk, Sophia, et al. "Regulation of Energy Metabolism during Early B Lymphocyte Development." International Journal of Molecular Sciences 19.8 (2018).

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