TILGen study-immunological targets in patients with breast cancer : Influence of tumor-infiltrating lymphocytes

Journal article


Publication Details

Author(s): Erber R, Hartmann A, Beckmann M, Mackensen A, Kremer A, Reimann H, Hübner H, Hein A, Lux MP, Jud S, Häberle L, Gaß P, Volz B, Schulz-Wendtland R, Rübner M, Fasching P
Journal: Pathologe
Publication year: 2018
Volume: 39
Journal issue: Suppl 2
Pages range: 236-240
ISSN: 0172-8113


Abstract

BACKGROUND: The interaction of our immune system with breast cancer (BC) cells prompted the investigation of tumor-infiltrating lymphocytes (TILs) and targeted, tumor antigen-specific immunotherapy.
OBJECTIVES: Correlation between TILs and pathological complete response (pCR) after neoadjuvant systemic therapy (NACT). Tumor-specific antigens (TSAs) in HER2+ and triple negative BC and establishment of TSA-specific therapies within the interdisciplinary TILGen study.
METHODS: Illustration of the TILGen study design. Assessment of TILs and correlation with pCR within this BC study.
RESULTS: pCR was achieved in 38.4% (56/146) and associated with estrogen receptor/progesterone receptor negative (ER-/PR-) and HER2+ tumors. Lymphocytic predominant BC (LPBC) was found in 16.4% (24/146), particularly in ER-/PR- (ER-: 27.3% vs. ER+: 9.9%, PR-: 22.3% vs. PR+: 8.2%), large, and poorly differentiated BC. TILs were significantly correlated with pCR in multivariate analysis. In LPBC, pCR was achieved in 66.7%, whereas it was 32.8% in non-LPBC.
CONCLUSIONS: First results confirm the influence of the human immune system on the response to NACT in HER2+ and triple negative BC. TSA-specific immunotherapy might improve the outcome in BC patients but there is an urgent need for comprehensive studies to further investigate this issue.


FAU Authors / FAU Editors

Beckmann, Matthias Prof. Dr.
Lehrstuhl für Geburtshilfe und Frauenheilkunde
Erber, Ramona Dr. med.
Pathologisches Institut
Fasching, Peter PD Dr.
Professur für Translationale Frauenheilkunde und Geburtshilfe
Gaß, Paul Dr. med.
Frauenklinik
Hartmann, Arndt Prof. Dr. med.
Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie
Hein, Alexander PD Dr.
Frauenklinik
Hübner, Hanna Dr. rer. nat.
Frauenklinik
Jud, Sebastian Dr.
Frauenklinik
Kremer, Anita PD Dr.
Medizinische Klinik 5 - Hämatologie und Internistische Onkologie
Mackensen, Andreas Prof. Dr.
Lehrstuhl für Innere Medizin V
Reimann, Hannah
Medizinische Klinik 5 - Hämatologie und Internistische Onkologie
Rübner, Matthias PD Dr.
Frauenklinik


How to cite

APA:
Erber, R., Hartmann, A., Beckmann, M., Mackensen, A., Kremer, A., Reimann, H.,... Fasching, P. (2018). TILGen study-immunological targets in patients with breast cancer : Influence of tumor-infiltrating lymphocytes. Pathologe, 39(Suppl 2), 236-240. https://dx.doi.org/10.1007/s00292-018-0526-7

MLA:
Erber, Ramona, et al. "TILGen study-immunological targets in patients with breast cancer : Influence of tumor-infiltrating lymphocytes." Pathologe 39.Suppl 2 (2018): 236-240.

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Last updated on 2019-18-07 at 07:22

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