ISCEV extended protocol for the photopic On-Off ERG
Sustar M, Holder GE, Kremers J, Barnes CS, Lei B, Khan NW, Robson AG (2018)
Publication Type: Journal article, Original article
Publication year: 2018
Journal
Book Volume: 136
Pages Range: 199-206
Journal Issue: 3
DOI: 10.1007/s10633-018-9645-y
Abstract
The International Society for Clinical Electrophysiology of Vision (ISCEV) standard for full-field electroretinography (ERG) describes a minimum procedure, but encourages more extensive testing. This ISCEV extended protocol describes an extension to the ERG standard, namely the photopic On-Off ERG, and outlines common clinical applications. A light stimulus duration of 150-200 ms is used in the presence of a rod-suppressing background to elicit cone-driven On- and Off-system ERG components. The On-response occurs after the stimulus onset and has a negative a-wave and positive b-wave. The Off d-wave is a positive component evoked by stimulus offset. Common diagnoses that may benefit from additional photopic On-Off ERG testing include retinal dystrophies and retinal disorders that cause dysfunction at a level that is post-phototransduction or post-receptoral. On-Off ERGs assess the relative involvement of On- and Off-systems and may be of use in the diagnosis of disorders such as complete and incomplete congenital stationary night blindness (complete and incomplete CSNB), melanoma-associated retinopathy, and some forms of autoimmune retinopathy. The photopic On-Off ERGs may also be useful in X-linked retinoschisis, Batten disease, Duchenne muscular dystrophy, spinocerebellar degeneration, quinine toxicity, and other retinal disorders.
Authors with CRIS profile
Involved external institutions
Moorfields Eye Hospital NHS Foundation Trust
United Kingdom (GB)
Ljubljana University Medical Centre (Ljubljana UMC) / Univerzitetni klinični center Ljubljana
Slovenia (SI)
University of Michigan
United States (USA) (US)
United Kingdom (GB)
Ljubljana University Medical Centre (Ljubljana UMC) / Univerzitetni klinični center Ljubljana
Slovenia (SI)
University of Michigan
United States (USA) (US)
How to cite
APA:
Sustar, M., Holder, G.E., Kremers, J., Barnes, C.S., Lei, B., Khan, N.W., & Robson, A.G. (2018). ISCEV extended protocol for the photopic On-Off ERG. Documenta Ophthalmologica, 136(3), 199-206. https://doi.org/10.1007/s10633-018-9645-y
MLA:
Sustar, Maja, et al. "ISCEV extended protocol for the photopic On-Off ERG." Documenta Ophthalmologica 136.3 (2018): 199-206.
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