Factors Influencing Central Lamina Cribrosa Depth: A Multicenter Study

Luo H, Yang H, Gardiner SK, Hardin C, Sharpe GP, Caprioli J, Demirel S, Girkin CA, Liebmann JM, Mardin CY, Quigley HA, Scheuerle AF, Fortune B, Chauhan BC, Burgoyne CF (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Investigative Ophthalmology & Visual Science Association for Research in Vision and Ophthalmology (ARVO)

Book Volume: 59

Pages Range: 2357-2370

Journal Issue: 6

DOI: 10.1167/iovs.17-23456

Abstract

Purpose: To quantify the influence of ocular and demographic factors on central laminar depth (LD) in healthy participants. Methods: A total of 362 normal subjects underwent optical coherence tomography (OCT) enhanced depth imaging of the optic nerve head (ONH) with a 24 radial B-scan pattern aligned to the fovea-to-Bruch's membrane opening (BMO) axis. BMO, anterior lamina, anterior scleral canal opening (ASCO), Bruch's membrane (BM), and the peripapillary scleral surface were manually segmented. The extent of laminar segmentation was quantified within 72 ASCO subsectors. Central LD was quantified relative to four reference planes: BMO, ASCO, BM, and scleral. The effects of age, sex, ethnicity, IOP, BMO area, ASCO area, and axial length on LD were assessed. Results: Laminar visibility was most consistent within the central ASCO (median 89%, range, 69%-95%). LDBMO and LDBM were significantly shallower in eyes with greater age, BMO area, and axial length and in females. LDASCO was shallower in eyes with greater ASCO area and axial length and in European and Hispanic descent compared to African descent eyes. LDSclera behaved similarly, but was not associated with axial length. BMO and ASCO area were not different between African descent and European descent eyes. Conclusions: Central LD was deeper in African descent eyes and influenced least by age, axial length, and sex, but more by ASCO area, when measured relative to the ASCO and sclera. However, the magnitude of these effects for all four reference planes was small, and their clinical importance in the detection of glaucoma and its progression remains to be determined.

Authors with CRIS profile

Christian Mardin Department of Ophthalmology

Involved external institutions

University of California Los Angeles (UCLA) US United States (USA) (US) Legacy Research Institute US United States (USA) (US) Ruprecht-Karls-Universität Heidelberg DE Germany (DE) University of Alabama at Birmingham (UAB) US United States (USA) (US) Dalhousie University CA Canada (CA) Icahn School of Medicine at Mount Sinai US United States (USA) (US) Central South University CN China (CN) Johns Hopkins University (JHU) US United States (USA) (US)

How to cite

APA:

Luo, H., Yang, H., Gardiner, S.K., Hardin, C., Sharpe, G.P., Caprioli, J.,... Burgoyne, C.F. (2018). Factors Influencing Central Lamina Cribrosa Depth: A Multicenter Study. Investigative Ophthalmology & Visual Science, 59(6), 2357-2370. https://dx.doi.org/10.1167/iovs.17-23456

MLA:

Luo, Haomin, et al. "Factors Influencing Central Lamina Cribrosa Depth: A Multicenter Study." Investigative Ophthalmology & Visual Science 59.6 (2018): 2357-2370.

BibTeX: Download