FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis

Journal article


Publication Details

Author(s): Schäffner I, Minakaki G, Khan MA, Balta EA, Schlötzer-Schrehardt U, Schwarz TJ, Beckervordersandforth R, Winner B, Webb AE, Webb AE, Depinho RA, Paik J, Wurst W, Klucken J, Lie DC
Journal: Neuron
Publication year: 2018
Volume: 99
Journal issue: 6
Pages range: 1188-1203.e6
ISSN: 0896-6273


Abstract

Autophagy is a conserved catabolic pathway with emerging functions in mammalian neurodevelopment and human neurodevelopmental diseases. The mechanisms controlling autophagy in neuronal development are not fully understood. Here, we found that conditional deletion of the Forkhead Box O transcription factors FoxO1, FoxO3, and FoxO4 strongly impaired autophagic flux in developing neurons of the adult mouse hippocampus. Moreover, FoxO deficiency led to altered dendritic morphology, increased spine density, and aberrant spine positioning in adult-generated neurons. Strikingly, pharmacological induction of autophagy was sufficient to correct abnormal dendrite and spine development of FoxO-deficient neurons. Collectively, these findings reveal a novel link between FoxO transcription factors, autophagic flux, and maturation of developing neurons.


FAU Authors / FAU Editors

Balta, Elli-Anna
Lehrstuhl für Biochemie und Pathobiochemie
Klucken, Jochen Prof. Dr.
Molekular-Neurologische Abteilung in der Neurologischen Klinik
Lie, Dieter Chichung Prof. Dr.
Institut für Biochemie
Minakaki, Georgia
Professur für Molekulare Neurologie
Schäffner, Iris Dr.
Institut für Biochemie
Schlötzer-Schrehardt, Ursula apl. Prof. Dr.
Medizinische Fakultät
Winner, Beate Prof. Dr.
Professur für Stammzell-Modelle seltener neuraler Erkrankungen


External institutions
Brown University
Cornell University
Technische Universität München (TUM)
University of Texas MD Anderson Cancer Center


How to cite

APA:
Schäffner, I., Minakaki, G., Khan, M.A., Balta, E.-A., Schlötzer-Schrehardt, U., Schwarz, T.J.,... Lie, D.C. (2018). FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis. Neuron, 99(6), 1188-1203.e6. https://dx.doi.org/10.1016/j.neuron.2018.08.017

MLA:
Schäffner, Iris, et al. "FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis." Neuron 99.6 (2018): 1188-1203.e6.

BibTeX: 

Last updated on 2018-19-12 at 15:08