Mammary Analog Secretory Carcinoma of the Nasal Cavity Characterization of 2 Cases and Their Distinction From Other Low-grade Sinonasal Adenocarcinomas

Baneckova M, Agaimy A, Andreasen S, Vanecek T, Steiner P, Slouka D, Svoboda T, Miesbauerova M, Michal M, Skalova A (2018)

Publication Type: Journal article

Publication year: 2018

Journal

American Journal of Surgical Pathology Lippincott, Williams & Wilkins

Book Volume: 42

Pages Range: 735-743

Journal Issue: 6

DOI: 10.1097/PAS.0000000000001048

Abstract

Secretory carcinoma, originally described as mammary analog secretory carcinoma (MASC), is a low-grade salivary gland tumor characterized by a t(12;15)(p13;q25) translocation, resulting in an ETV6-NTRK3 gene fusion. Most MASCs are localized to the parotid gland and intraoral minor salivary glands. Moreover, ETV6-rearranged carcinomas with secretory features have been reported recently in the thyroid (with and without a history of radiation exposure), skin, and in very rare instances in the sinonasal tract. Here, we describe 2 cases of primary MASC in the sinonasal tract and provide a detailed clinical and histopathologic characterization of their morphology, immunohistochemical profile, and genetic background and highlight features allowing for its separation from its recently described molecular mimicker, ETV6-rearranged low-grade sinonasal adenocarcinoma.

Authors with CRIS profile

Abbas Agaimy Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie

Involved external institutions

Univerzita Karlova v Praze / Charles University in Prague CZ Czech Republic (CZ) Køge University Hospital DK Denmark (DK) Biopticka laborator s.r.o. CZ Czech Republic (CZ)

How to cite

APA:

Baneckova, M., Agaimy, A., Andreasen, S., Vanecek, T., Steiner, P., Slouka, D.,... Skalova, A. (2018). Mammary Analog Secretory Carcinoma of the Nasal Cavity Characterization of 2 Cases and Their Distinction From Other Low-grade Sinonasal Adenocarcinomas. American Journal of Surgical Pathology, 42(6), 735-743. https://doi.org/10.1097/PAS.0000000000001048

MLA:

Baneckova, Martina, et al. "Mammary Analog Secretory Carcinoma of the Nasal Cavity Characterization of 2 Cases and Their Distinction From Other Low-grade Sinonasal Adenocarcinomas." American Journal of Surgical Pathology 42.6 (2018): 735-743.

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