High-grade myoepithelial carcinoma can show histologically undifferentiated/anaplastic features
Mok Y, Agaimy A, Wang S, Kuick CH, Chang KTE, Petersson F (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 37
Pages Range: 20-24
DOI: 10.1016/j.anndiagpath.2018.09.004
Abstract
High grade malignant tumors with a poorly-/un-differentiated morphology pose significant diagnostic challenges. Increasingly, the use of adjunct immunohistochemical and molecular tests to characterize and delineate the histopathologic phenotype of these tumors has become necessary, particularly in head and neck tumors. Recently, several entities with a poorly-/un-differentiated light microscopic morphology have been defined based on specific immunohistochemical and genetic characteristics. We herein describe two cases of high-grade myoepithelial carcinoma, one occurring in the submandibular gland and the other occurring in the left nasal cavity, both showing undifferentiated histological and anaplastic cytomorphological features. This led to very broad differential diagnostic considerations and the diagnosis was only established after extensive immunohistochemical studies. Molecular testing for HPV was negative in both cases. Gene fusion analysis using a targeted sequencing assay (Archer® FusionPlex® system) did not identify fusions involving PLAG1, HMGA2, EWSR1 or ALK genes in either case. The submandibular tumor showed an aggressive clinical course, with diffuse pulmonary metastases at presentation, whilst the nasal cavity tumor showed only localized disease. Awareness of a subcategory of high-grade myoepithelial carcinomas with undifferentiated light microscopical features is of significant importance in antibody selection for immunohistochemical investigation of poorly-/undifferentiated malignant tumors in the head and neck region. This histological variant of myoepithelial carcinoma adds to the growing list of differential diagnoses in this diagnostically complex and multifaceted field.
Authors with CRIS profile
Involved external institutions
National University Health System (NUHS)
Singapore (SG)
Duke-NUS Medical School / 杜克—国大医学研究生院
Singapore (SG)
Singapore (SG)
Duke-NUS Medical School / 杜克—国大医学研究生院
Singapore (SG)
How to cite
APA:
Mok, Y., Agaimy, A., Wang, S., Kuick, C.H., Chang, K.T.E., & Petersson, F. (2018). High-grade myoepithelial carcinoma can show histologically undifferentiated/anaplastic features. Annals of Diagnostic Pathology, 37, 20-24. https://dx.doi.org/10.1016/j.anndiagpath.2018.09.004
MLA:
Mok, Yingting, et al. "High-grade myoepithelial carcinoma can show histologically undifferentiated/anaplastic features." Annals of Diagnostic Pathology 37 (2018): 20-24.
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