Whither systems medicine?

Apweiler R, Beissbarth T, Berthold MR, Bluethgen N, Burmeister Y, Dammann O, Deutsch A, Feuerhake F, Franke A, Hasenauer J, Hoffmann S, Hoefer T, Jansen PLM, Kaderali L, Klingmueller U, Koch I, Kohlbacher O, Kuepfer L, Lammert F, Maier D, Pfeifer N, Radde N, Rehm M, Roeder I, Saez-Rodriguez J, Sax U, Schmeck B, Schuppert A, Seilheimer B, Theis FJ, Vera J, Wolkenhauer O (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Book Volume: 50

Journal Issue: 3

DOI: 10.1038/emm.2017.290

Abstract

New technologies to generate, store and retrieve medical and research data are inducing a rapid change in clinical and translational research and health care. Systems medicine is the interdisciplinary approach wherein physicians and clinical investigators team up with experts from biology, biostatistics, informatics, mathematics and computational modeling to develop methods to use new and stored data to the benefit of the patient. We here provide a critical assessment of the opportunities and challenges arising out of systems approaches in medicine and from this provide a definition of what systems medicine entails. Based on our analysis of current developments in medicine and healthcare and associated research needs, we emphasize the role of systems medicine as a multilevel and multidisciplinary methodological framework for informed data acquisition and interdisciplinary data analysis to extract previously inaccessible knowledge for the benefit of patients.

Authors with CRIS profile

Involved external institutions

Biologische Heilmittel Heel GmbH Germany (DE) Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich Germany (DE) Max Planck Institute for Informatics / Max-Planck-Institut für Informatik Germany (DE) Universitätsklinikum Heidelberg Germany (DE) Universität Stuttgart Germany (DE) Biomax Informatics AG Germany (DE) Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen Germany (DE) Technische Universität Dresden Germany (DE) The European Bioinformatics Institute (EBI) United Kingdom (GB) Justus-Liebig-Universität Gießen Germany (DE) Universitätsklinikum Göttingen Germany (DE) Goethe-Universität Frankfurt am Main Germany (DE) Eberhard Karls Universität Tübingen Germany (DE) Christian-Albrechts-Universität zu Kiel Germany (DE) Universität Konstanz Germany (DE) Maastricht University Netherlands (NL) Deutsches Krebsforschungszentrum (DKFZ) Germany (DE) Universität Leipzig Germany (DE) Universität des Saarlandes (UdS) Germany (DE) Medizinische Hochschule Hannover (MHH) / Hannover Medical School Germany (DE) Tufts University United States (USA) (US) Charité - Universitätsmedizin Berlin Germany (DE) Universitätsmedizin Greifswald / Universitätsklinikum Greifswald Germany (DE) Universität Rostock Germany (DE)

How to cite

APA:

Apweiler, R., Beissbarth, T., Berthold, M.R., Bluethgen, N., Burmeister, Y., Dammann, O.,... Wolkenhauer, O. (2018). Whither systems medicine? Experimental and Molecular Medicine, 50(3). https://dx.doi.org/10.1038/emm.2017.290

MLA:

Apweiler, Rolf, et al. "Whither systems medicine?" Experimental and Molecular Medicine 50.3 (2018).

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